AG Kalisch
Leitung:
Prof. Dr. Raffael Kalisch
Research Group Leader LIR, Director of Neuroimaging Center Mainz, Professor of Human Neuroimaging
Dr. Benjamin Meyer, Postdoktorand
Papoula Petri-Romão, Doktorandin
Dr. Lara Puhlmann, Doktorandin
Dr. Kenneth S.L. Yuen, Postdoktorand
Elena Andres, Postdoktorandin
Dogukan Koc, Doktorand
Frédérique Maas, Doktorandin
Maximilian Lückel, Doktorand
Matthias Zerban, Doktorand
Lisanne van Houtum, Postdoktorandin
Ajna Jansson, Doktorandin
Wir erforschen grundlegende Mechanismen der Resilienz im Menschen auf kognitiver und neurofunktionaler Ebene und streben die Formulierung einer umfassenden und vereinheitlichenden Theorie der Resilienz an. Dabei legen wir einen dynamischen Resilienzbegriff zugrunde, der Resilienz als Ergebnis eines Anpassungprozesses an Stressoren sieht. Wichtiges Instrument sind daher prospektive Längsschnittstudien (MARP, LORA, DynaM-OBS, DynaCORE-L) und interventionelle (DynaM-INT, RESPOND) prospektive Längsschnittstudien, in denen Veränderungen in biologischen und psychologischen Funktionen über die Zeit und in Abhängigkeit von der Stressorexposition und in ihrer Bedeutung für die Aufrechterhaltung der psychischen Gesundheit betrachtet werden. Ein anderes wichtiges Instrument ist die rechnergestützte Analyse und Modellierung dieser Datensätze. Darüber hinaus führen wir mit Methoden der Experimentalpsychologie, Hirnbildgebung (MRT), Hirnstimulation (TMS, TUS), Pharmakologie und Psychophysiologie Laborstudien zu den kognitiven und neuralen Grundlagen identifzierter Resilienzmechanismen wie Extinktion und kognitive Emotionsregulation durch.
- Längsschnittstudie "Longitudinal Resilience Assessment" (LORA)
- Längsschnittstudie "Mainzer Resilienz-Projekt" (MARP)
- EU-Konsortialprojekt " Running in the FAMILY – Understanding and predicting the intergenerational transmission of mental illness" (FAMILY)
- Konsortialprojekt DEPARTMENTS OF DEFENCE AND VETERANS’ AFFAIRS, Australien “A multi-systems approach to demand and resilience resource profiles within the at-sea deployment setting”
- Konsortialprojekt "Pharmacological Augmentation of Stress Resilience - Proof of Principle" (PHASR-PP)
- Konsortialprojekt "Understanding Growth in Emotion Regulatory Flexibility in Emerging Adults" (Australian Research Council)
- SFB1193-Teilprojekt "Rolle spontaner Aktivität in einem mesopräfontalen Schaltkreis bei der Langzeit-Konsolidierung des Extinktionsgedächtnisses"
- Josep Maria Haro Abad, Psychiatry at University of Barcelona, Spanien
- Jose Luis Ayuso, Department of Psychiatry of Autonomous University of Madrid and La Princesa Teaching Hospital Madrid, Spanien
- Christian Beckmann, Radboud University Medical Centre (Radboudumc) · Department of Cognitive Neuroscience, Nijmegen, Niederlande
- Harald Binder, Institut für Medizinische Biometrie und Informatik, Universität Freiburg, Deutschland
- Richard Bryant, School of Psychology, University of New South Wales, Sydney, Australia
- Erno Hermans, Donders Institute, Radboud University Nijmegen, Netherlands
- Birgit Kleim, Institute of Psychology, Universität Zürich, Schweiz
- Dorota Kobylinska, Faculty of Psychology, University of Warsaw, Polen
- Signe Mezinska, Faculty of Medicine, University of Latvia, Lettland
- Inez Myin-Germeys, Contextual Psychiatry, Catholic University Leuven, Belgium
- Andreas Reif, Klinik für Psychiatrie und Psychotherapie, Universitätsklinik der Goethe Universität Frankfurt, Deutschland
- Karin Roelofs, Donders Institute, Radboud University Nijmegen, Netherlands
- Marit Sijbrandij, Faculty of Behavioural and Movement Sciences, Clinical Psychology, Free University of Amsterdam, Netherlands
- Jens Timmer, Institute for Physics, University of Freiburg, Germany
- Neeltje van Haren, Department of Child psychiatry at Erasmus MC Sophia Children’s Hospital Rotterdam, Niederlande
- Henrik Walter, Klinik für Psychiatrie, Charité Berlin, Deutschland
- Monique Crane, Institute of Psychology, Macquarie University, Sydney
- Flurin Cathomas, Department of Psychiatry, University Zurich
- Emma Sprooten, Radboud University Medical Centre (Radboudumc) · Department of Cognitive Neuroscience, Nijmegen, Niederlande
- Michael Plichta, Department of Psychiatry and Psychotherapy, University Hospital, Goethe University Frankfurt a.M., Germany
- Marta Marciniak, Erasmus School of Social and Behavioural Sciences, Erasmus University Rotterdam, Netherlands
- Ken-Ichiro Tsutsui, Graduate School of Life Sciences, Tohoku University, Sendai, Japan
- Katharina Schultebraucks, Data Science Institute at Columbia University, New York, USA
- Talma Hendler, Functional Brain Center, Tel Aviv University, Israel
- EU Horizon
- ERA-NET Neuron
- DFG
Ahrens KF, Schenk C, Kollmann B, Puhlmann LMC, Neumann RJ, Schäfer SK, Reis D, Basten U, Weichert D, Fiebach CJ, Lutz B, Wessa M, Repple J, Lieb K, Tüscher O, Reif A, Kalisch R, Plichta MM. Resilience to major life events: Advancing trajectory modeling and resilience factor identification by controlling for background stressor exposure. Am Psychol. 2024 Nov;79(8):1076-1091. doi: 10.1037/amp0001315. PMID: 39531708.
>> Link zu PubmedKalisch R, Russo SJ, Müller MB. Neurobiology and systems biology of stress resilience. Physiol Rev. 2024 Jul 1;104(3):1205-1263. doi: 10.1152/physrev.00042.2023. Epub 2024 Mar 14. PMID: 38483288; PMCID: PMC11381009.
>> Link zu PubmedAndres E, Chuan-Peng H, Gerlicher AMV, Meyer B, Tüscher O, Kalisch R. Replication study on the role of dopamine-dependent prefrontal reactivations in human extinction memory retrieval. Nat Commun. 2024 Mar 27;15(1):2699. doi: 10.1038/s41467-024-46936-y. PMID: 38538636; PMCID: PMC10973457.
>> Link zu PubmedPetri-Romão P, Engen H, Rupanova A, Puhlmann L, Zerban M, Neumann RJ, Malyshau A, Ahrens KF, Schick A, Kollmann B, Wessa M, Walker H, Plichta MM, Reif A, Chmitorz A, Tuescher O, Basten U, Kalisch R. Self-report assessment of Positive Appraisal Style (PAS): Development of a process-focused and a content-focused questionnaire for use in mental health and resilience research. PLoS One. 2024 Feb 2;19(2):e0295562. doi: 10.1371/journal.pone.0295562. PMID: 38306328; PMCID: PMC10836662.
>> Link zu PubmedAyash S, Lingner T, Ramisch A, Ryu S, Kalisch R, Schmitt U, Müller MB. Fear circuit-based neurobehavioral signatures mirror resilience to chronic social stress in mouse. Proc Natl Acad Sci U S A. 2023 Apr 25;120(17):e2205576120. doi: 10.1073/pnas.2205576120. Epub 2023 Apr 17. PMID: 37068238; PMCID: PMC10151471.
>> Link zu PubmedKöber G, Pooseh S, Engen H, Chmitorz A, Kampa M, Schick A, Sebastian A, Tüscher O, Wessa M, Yuen KSL, Walter H, Kalisch R, Timmer J, Binder H (2022). Individualizing deep dynamic models for psychological resilience data. Sci Rep. 2022 May 16;12(1):8061. doi: 10.1038/s41598-022-11650-6
>> Link zu PubmedSchäfer SK, Kunzler AM, Kalisch R, Tüscher O, Lieb K (2022). Trajectories of resilience and mental distress to global major disruptions. Trends Cogn Sci. 2022 Oct 24:S1364-6613(22)00238-8. doi: 10.1016/j.tics.2022.09.017. Online ahead of print
>> Link zu PubmedKalisch R, Köber G, Binder H, Ahrens KF, Basten U, Chmitorz A, Choi KW, Fiebach CJ, Goldbach N, Neumann RJ, Kampa M, Kollmann B, Lieb K, Plichta MM, Reif A, Schick A, Sebastian A, Walter H, Wessa M, Yuen KSL, Tüscher O, Engen H (2021). The Frequent Stressor and Mental Health Monitoring-Paradigm: A Proposal for the Operationalization and Measurement of Resilience and the Identification of Resilience Processes in Longitudinal Observational Studies. Front Psychol. 12:710493.
>> Link zu PubmedKöber G, Kalisch R, Puhlmann L, Chmitorz A, Schick A, Binder H (2021) Deep learning and differential equations for modeling changes in individual-level latent dynamics between observation periods. Biometrical Journal. 52. In press
>> Link zu PubmedVeer et al (2021) Psycho-social factors associated with mental resilience in the Corona lockdown. Transl Psychiatry 11:67.
>> Link zu PubmedUngar M et al (2021) Multisystemic Resilience: Adaptation and Transformation in Contexts of Change
>> Link zum ArtikelChmitorz A, Kurth K, Mey LK, Wenzel M, Lieb K, Tüscher O, Kubiak T, Kalisch R (2020). Assessment of microstressors in adults: Questionnaire development and ecological validation of the Mainz Inventory of Microstressors. JMIR Ment Health 7(2):e14566.
>> Link zu PubmedKampa M, Schick A, Sebastian A, Wessa M, Tüscher O, Kalisch R, Yuen K (2020). Replication of fMRI group activations in the neuroimaging battery for the Mainz Resilience Project (MARP). Neuroimage 204:116223.
>> Link zu PubmedKalisch R, Gerlicher AMV, Duvarci S (2019). A Dopaminergic Basis for Fear Extinction. Trends Cogn Sci 23(4):274-277.
>> Link zu PubmedGerlicher AMV, Tüscher O, Kalisch R. Dopamine-dependent prefrontal reactivations explain long-term benefit of fear extinction. Nat Commun. 2018 Oct 16;9(1):4294. doi: 10.1038/s41467-018-06785-y. Erratum in: Nat Commun. 2019 Jan 23;10(1):471. doi: 10.1038/s41467-019-08399-4. PMID: 30327462; PMCID: PMC6191435.
>> Link zu PubmedSalinas-Hernández XI, Vogel P, Betz S, Kalisch R, Sigurdsson T, Duvarci S. Dopamine neurons drive fear extinction learning by signaling the omission of expected aversive outcomes. Elife. 2018 Nov 13;7:e38818. doi: 10.7554/eLife.38818. PMID: 30421719; PMCID: PMC6257816.
>> Link zu PubmedKalisch R, Baker DG, Basten U, Boks MP, Bonanno GA, Brummelman E, Chmitorz A, Fernàndez G, Fiebach CJ, Galatzer-Levy I, Geuze E, Groppa S, Helmreich I, Hendler T, Hermans EJ, Jovanovic T, Kubiak T, Lieb K, Lutz B, Müller MB, Murray RJ, Nievergelt CM, Reif A, Roelofs K, Rutten BPF, Sander D, Schick A, Tüscher O, Diest IV, Harmelen AV, Veer IM, Vermetten E, Vinkers CH, Wager TD, Walter H, Wessa M, Wibral M, Kleim B (2017). The resilience framework as a strategy to combat stress-related disorders. Nat Hum Behav 1(11):784-790.
>> Link zu PubmedKalisch R, Müller MB, Tüscher O (2015). A conceptual framework for the neurobiological study of resilience. Behav Brain Sci ;38:e92.
>> Link zu PubmedHaaker J, Gaburro S, Sah A, Gartmann N, Lonsdorf TB, Meier K, Singewald N, Pape HC, Morellini F*, Kalisch R* (2013) Single dose of L-dopa makes extinction memories context-independent and prevents the return of fear. PNAS 110:E2428-36
>> Link zu PubmedRaczka KA, Mechias ML, Gartmann N, Reif A, Deckert J, Pessiglione M, Kalisch R. Empirical support for an involvement of the mesostriatal dopamine system in human fear extinction. Transl Psychiatry. 2011 Jun 7;1(6):e12. doi: 10.1038/tp.2011.10. PMID: 22832428; PMCID: PMC3309464.
>> Link zu PubmedEtkin A, Egner T, Kalisch R (2011) Emotional processing in anterior cingulate and medial prefrontal cortex. Trends Cogn Sci 15:85-93.
>> Link zu PubmedRaczka KA, Gartmann N, Mechias ML, Reif A, Buchel C, Deckert J, Kalisch R (2010) A neuropeptide S receptor variant associated with overinterpretation of fear reactions: a potential neurogenetic basis for catastrophizing. Mol Psychiatry 15:1067−1074. Corrigendum: 17:468.
>> Link zu PubmedKalisch R (2009) The functional neuroanatomy of reappraisal: time matters. Neurosci Biobehav Rev 33:1215-26.
>> Link zu PubmedPessiglione M, Schmidt L, Draganski B, Kalisch R, Lau H, Dolan RJ, Frith CD (2007) How the brain translates money into force: a neuroimaging study of subliminal motivation. Science 316:904−906.
>> Link zu Pubmed