Prof. Dr. Beat Lutz
Scientific Managing Director LIR, Professor and Director of Institute of Physiological Chemistry University Medical Center of the Johannes Gutenberg-University Mainz
Leibniz-Institut für Resilienzforschung gGmbH
Wallstraße 7
55122 Mainz
Sekretariat (8:30 - 15:00)
E-Mail:
verena.huber@lir-mainz.de
Telefon:
+49 (0)6131-89448-77
Behavioral Genetics in mouse. Mechanisms underlying learning and memory, and stress coping. Epigenetic mechanisms underlying behavior. Lipid signaling systems (mainly on endocannabinoids and cannabinoid receptors). Roles of the endocannabinoid system in anxiety, fear memory, stress coping, synaptic plasticity, adult neurogenesis, neural development, and energy metabolism.
1961
Scientific Managing Director and Research Group Leader Leibniz Institute for Resilience Research (LIR), Mainz, Germany
Professor and Director at Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg-University Mainz
Habilitation in Zoology at the LMU Munich, Germany (Prof. G. Neuweiler)
Diploma for Gymnasium teacher in Chemistry, ETH, Switzerland
Dr. sc. nat: ETH Zurich Switzerland
Doctorate work at the Institute for Cell Biology, ETH Zurich, Switzerland (Prof. M. Lezzi, Prof. H. Eppenberger)
Diploma in Natural Sciences at ETH Zurich, Switzerland
Studies in Biochemistry at ETH Zurich, Switzerland
Habilitation in Zoology at the LMU Munich, Germany (Prof. G. Neuweiler)
Scientific Managing Director and Research Group Leader, Leibniz Institute for Resilience Research (LIR), Mainz, German
Director of the Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
W3 Professor for Physiological Chemistry, Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University, Mainz, Germany
Independent Group Leader of the Max Planck Society at the Max Planck Institute of Psychiatry, Munich, Germany
Scientist at the DKFZ, Heidelberg, Germany (Prof. G. Schütz)
Postdoctoral positions at ETH Zurich, Switzerland (Prof. M. Lezzi), Harvard Medical School, Boston, MA USA (Prof. G. Eichele), and Baylor College of Medicine, Houston, TX, USA (Prof. G. Eichele)
Spokesperson of the CRC1193 „Neurobiology of Resilience“
Tenure Commission at UM Mainz, Germany
Co-organizer of the International Symposium on Resilience Research
Member of Fachbereichsrat at UM Mainz, Germany
Mechoulam Award for Outstanding Contributions to Cannabinoid Research
Chair of the Gordon Research Conference “Cannabinoid Functions in the CNS”
Spokesperson of DFG Research Unit FOR926 (with A. Zimmer, Bonn, Germany)
Stipend from the Hertie Foundation (Excellence Program in Neurosciences)
Organon Prize for Psychiatry
Fellowships from the Swiss National Foundation
Herr Professor Dr. Beat Lutz ist seit 2004 Professor für physiologische Chemie an der Universitätsmedizin Mainz, dort Direktor des Instituts für Physiologische Chemie und seit 2020 wissenschaftlicher Direktor und Arbeitsgruppenleiter am Leibniz-Institut für Resilienzforschung. Er hat seit 2018 keine persönlichen Honorare für Beratertätigkeiten, Fortbildungsveranstaltungen, Vorträge oder Stellungnahmen von pharmazeutischen Unternehmen oder Medizinprodukteherstellern erhalten. Von der gemeinnützigen Boehringer Ingelheim Stiftung erhielt Prof. Lutz zusammen mit anderen Wissenschaftlerinnen und Wissenschaftlern Forschungsmittel für die Jahre 2017-2020 zum Aufbau des Leibniz-Instituts für Resilienzforschung.
Busquets-Garcia A, Gomis-Gonzalez M, Srivastava RK, Cutando L, Ortega-Alvaro A, Ruehle S, Remmers F, Bindila L, Bellocchio L, Marsicano G, Lutz B*, Maldonado R*, Ozaita A* (2016) Peripheral and central CB1 cannabinoid receptors control stress-induced impairment of memory consolidation. Proc Natl Acad Sci USA 113(35):9904−9909. *equal contribution
>> Link zu PubmedDomingo-Rodriguez L, Ruiz de Azua I, Dominguez E, Senabre E, Serra I, Kummer S, Navandar M, Baddenhausen S, Hofmann C, Andero R, Gerber S, Navarrete M, Dierssen M, Lutz B*, Martín-García E*, Maldonado R* (2020) A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction. Nat Commun 11(1):782. doi: 10.1038/s41467-020-14458-y. (*equal contributions)
>> Link zu PubmedLange MD, Daldrup T, Remmers F, Szkudlarek HJ, Lesting J, Guggenhuber S, Ruehle S, Jungling K, Sei-denbecher T, Lutz B, Pape HC (2017) Cannabinoid CB1 receptors in distinct circuits of the extended amygdala determine fear responsiveness to unpredictable threat. Mol Psychiatry 22(10):1422−1430.
>> Link zu PubmedLeschik J, Gentile A, Cicek C, Péron S, Tevosian M, Beer A, Radyushkin K, Bludau A, Ebner K, Neumann I, Singewald N, Berninger B, Lessmann V, Lutz B (2022) Brain-derived neurotrophic factor expression in serotonergic neurons improves stress resilience and promotes adult hippocampal neurogenesis. Prog Neurobiol 217:102333. doi: 10.1016/j.pneurobio.2022.102333.
>> Link zu PubmedLomazzo E, Bindila L, Remmers F, Lerner R, Schwitter C, Hoheisel U, Lutz B (2015) Therapeutic potential of inhibitors of endocannabinoid degradation for the treatment of stress-related hyperalgesia in an animal model of chronic pain. Neuropsychopharmacol 40:488-501.
>> Link zu PubmedMarsicano G, Wotjak CW, Azad SC, Bisogno T, Rammes G, Song T, Hofmann C, Zieglgänsberger W, Di Marzo V, Lutz B (2002) The endogenous cannabinoid system controls extinction of aversive memories. Nature 418:530-5.
>> Link zu PubmedMonory K, Massa F, Egertova M, Eder M, Blaudzun H, Westenbroek R, Kelsch W, Jacob W, Marsch R, Ekker M, Long J, Rubenstein JL, Goebbels S, Nave KA, During M, Klugmann M, Wolfel B, Dodt HU, Zieglgänsberger W, Wotjak CT, Mackie K, Elphick MR, Marsicano G, Lutz B (2006) The endocanna-binoid system controls key epileptogenic circuits in the hippocampus. Neuron 51:455−466.
>> Link zu PubmedRey AA, Purrio M, Viveros MP, Lutz B (2012) Biphasic effects of cannabinoids in anxiety responses: CB1 and GABAB receptors in the balance of GABAergic and glutamatergic neurotransmission. Neuropsychopharmacol 37:2624–34.
>> Link zu PubmedRuiz de Azua I, Mancini G, Srivastava RK, Rey AA, Cardinal P, Tedesco L, Zingaretti CM, Sassmann A, Quarta C, Schwitter C, Conrad A, Wettschureck N, Vemuri VK, Makriyannis A, Hartwig J, Mendez-Lago M, Bindila L, Monory K, Giordano A, Cinti S, Marsicano G, Offermanns S, Nisoli E, Pagotto U, Cota D, Lutz B (2017) Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages. J Clin Invest 127(11):4148−4162
>> Link zu PubmedVennin C, Hewel C, Todorov H, Wendelmuth M, Radyushkin K, Heimbach A, Horenko I, Ayash S, Müller MB, Schweiger S, Gerber S, Lutz B (2022) A Resilience Related Glial-Neurovascular Network Is Transcriptionally Activated after Chronic Social Defeat in Male Mice. Cells 11(21):3405. doi: 10.3390/cells11213405.Pascual Cuadrado D, Todorov H, Lerner R, Islami L, Bindila L, Gerber S, Lutz B (2022) Long-term molecular differences between resilient and susceptible mice after a single traumatic exposure. Br J Pharmacol 179(17):4161-4180. doi: 10.1111/bph.15697.
>> Link zu Pubmed