Hand over computer screen

Prof. Dr. Raffael Kalisch

Research Group Leader LIR, Director of Neuroimaging Center Mainz, Professor of Human Neuroimaging

Kontakt

Leibniz-Institut für Resilienzforschung gGmbH
Langenbeckstraße 1
55131 Mainz

+49 (0)6131 17-4588
General Information
Year of Birth

1972

Current Position

Research Group Leader, Leibniz Institute for Resilience Research (LIR), Mainz, Germany

Professor of Human Neuroimaging and Director of Neuroimaging Center (NIC), Mainz, University Medical Center of the Johannes Gutenberg-University Mainz, Germany

University training and degrees
10/1997 – 09/1998

Human Biology (Theoretical Medicine), University of Marburg, Germany; Dipl. Hum. biol. (supervisor: A. Triller, Ecole Normale Supérieure, Paris)

10/1996 – 09/1997

Maitrise de Biologie cellulaire et Physiologie, Université Paris VII, Paris, France; guest student without degree 

10/1993 – 09/1996

Human Biology (Theoretical Medicine), University of Marburg, Germany

Advanced academic qualifications
2002

Dr. rer. nat.: Biology, Ludwig Maximilian University Munich, Germany (supervisor: R. Landgraf, Max Planck Institute for Psychiatry, Munich)

 

Postgraduate professional career
Since 01/2020

Research Group Leader at the Leibniz Institute for Resilience Research (LIR), Mainz, Germany

Since 2020

Professor for Human Neuroimaging (W3) and Director, Neuroimaging Center Mainz (NIC), University Medical Center of the Johannes Gutenberg-University Mainz, Germany

01/2018 - 12/2019

Research Group Leader at the German Resilience Center (DRZ) Mainz, Germany

2012-2020

Professor for Human Neuroimaging (W2) and Director, Neuroimaging Center Mainz (NIC), University Medical Center of the Johannes Gutenberg University Mainz, Germany

01/2008 – 12/2012

DFG Emmy Noether Research Group Leader, Institute for Systems Neuroscience, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany

08/2007 – 12/2007

Research Group Leader, Institute for Systems Neuroscience, UKE, Hamburg, Germany

06/2006 – 07/2007

Postdoctoral researcher, Institute for Systems Neuroscience, UKE, Hamburg, Germany (supervisor: C. Büchel)

02/2003 – 04/2006

Postdoctoral researcher, Wellcome Department of Imaging Neuroscience, University College London, United Kingdom (supervisor: R. Dolan)

03/2002 – 01/2003

Postdoctoral researcher, NMR study group, Max Planck Institute for Psychiatry, Munich, Germany (supervisor: D. Auer)

11/1998 – 02/2002

Doctoral student, NMR study group, Max Planck Institute for Psychiatry, Munich, Germany (supervisors: D. Auer, R. Landgraf)

 

Other professional activities or honors
Since 2018

Secretary of intresa

Since 2018 - 2024

Coordinator EU Horizon 2020 project DynaMORE (Dynamic MOdelling of REsilience)

2016 – 2018

Founding spokesperson of intresa (International Resilience Alliance)

Since 2015

Initiator and main organizer of International Symposium on Resilience Research

2008 – 2012

DFG Emmy Noether Research Group

2003 – 2005

EU Marie Curie Individual Fellowship for postdoctoral studies

1997

Stipend of Medizinstiftung, University of Marburg for diploma studies at Ecole Normale Supérieure, Paris, France

 

Transparenz / Erklärung von Interessen

Professor Dr. Raffael Kalisch ist seit 2012 Universitätsprofessor für Human Neuroimaging an der Universitätsmedizin Mainz und seit 2020 Arbeitsgruppenleiter im Leibniz-Institut für Resilienzforschung. Er hat seit 2018 keine persönlichen Honorare für Stellungnahmen von pharmazeutischen Unternehmen oder Medizinprodukteherstellern erhalten. Zwischen 2019-2021 hat Prof. Kalisch Beratertätigkeiten, wie Förderantragsbegutachtungen und Gestaltungen von Förderprogrammen für die JoyVentures, Herzlia, in Israel ausgeübt. Von der gemeinnützigen Boehringer Ingelheim Stiftung erhielt Prof. Kalisch zusammen mit anderen Wissenschaftlerinnen und Wissenschaftlern des LIR Forschungsmittel für die Jahre 2017-2020 zum Aufbau des Leibniz-Instituts für Resilienzforschung. Er ist seit 2018 Vorstandsmitglied und Sekretär in der International Resilience Alliance (intresa e.V.).

Gutachterhonorare

2020

- Interdisziplinäres Zentrum für Klinische Forschung, RWTH Aachen

- Joy Ventures, Herzliya, Israel

Rednerhonorare

2023

- Berufsverband Deutscher Psychologinnen und Psychologen, Landesgruppe Saarland

- Besser-Siegmund-Institut GmbH, Hamburg

2022

- Hessische Landesstelle für Technologiefortbildung, Groß-Gerau

- Interdisziplinäres Zentrum für Klinische Forschung, RWTH Aachen

2021

- Institut für Selbstmanagement und Motivation Zürich

- Evangelische Stadtakademie München

2020

- Akademie Auswärtiger Dienst, Auswärtiges Amt

- Psychosomatisches Forschungskolloquium, Universität Ulm

- Stiftung Nantesbuch gGmbH

Selected Publications

Ahrens KF, Schenk C, Kollmann B, Puhlmann LMC, Neumann RJ, Schäfer SK, Reis D, Basten U, Weichert D, Fiebach CJ, Lutz B, Wessa M, Repple J, Lieb K, Tüscher O, Reif A, Kalisch R, Plichta MM. Resilience to major life events: Advancing trajectory modeling and resilience factor identification by controlling for background stressor exposure. Am Psychol. 2024 Nov;79(8):1076-1091. doi: 10.1037/amp0001315. PMID: 39531708.

>> Link zu Pubmed

Kalisch R, Russo SJ, Müller MB. Neurobiology and systems biology of stress resilience. Physiol Rev. 2024 Jul 1;104(3):1205-1263. doi: 10.1152/physrev.00042.2023. Epub 2024 Mar 14. PMID: 38483288; PMCID: PMC11381009.

>> Link zu Pubmed

Andres E, Chuan-Peng H, Gerlicher AMV, Meyer B, Tüscher O, Kalisch R. Replication study on the role of dopamine-dependent prefrontal reactivations in human extinction memory retrieval. Nat Commun. 2024 Mar 27;15(1):2699. doi: 10.1038/s41467-024-46936-y. PMID: 38538636; PMCID: PMC10973457.

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Petri-Romão P, Engen H, Rupanova A, Puhlmann L, Zerban M, Neumann RJ, Malyshau A, Ahrens KF, Schick A, Kollmann B, Wessa M, Walker H, Plichta MM, Reif A, Chmitorz A, Tuescher O, Basten U, Kalisch R. Self-report assessment of Positive Appraisal Style (PAS): Development of a process-focused and a content-focused questionnaire for use in mental health and resilience research. PLoS One. 2024 Feb 2;19(2):e0295562. doi: 10.1371/journal.pone.0295562. PMID: 38306328; PMCID: PMC10836662.

>> Link zu Pubmed

Ayash S, Lingner T, Ramisch A, Ryu S, Kalisch R, Schmitt U, Müller MB. Fear circuit-based neurobehavioral signatures mirror resilience to chronic social stress in mouse. Proc Natl Acad Sci U S A. 2023 Apr 25;120(17):e2205576120. doi: 10.1073/pnas.2205576120. Epub 2023 Apr 17. PMID: 37068238; PMCID: PMC10151471.

>> Link zu Pubmed

Köber G, Pooseh S, Engen H, Chmitorz A, Kampa M, Schick A, Sebastian A, Tüscher O, Wessa M, Yuen KSL, Walter H, Kalisch R, Timmer J, Binder H (2022). Individualizing deep dynamic models for psychological resilience data. Sci Rep. 2022 May 16;12(1):8061. doi: 10.1038/s41598-022-11650-6

>> Link zu Pubmed

Schäfer SK, Kunzler AM, Kalisch R, Tüscher O, Lieb K (2022). Trajectories of resilience and mental distress to global major disruptions. Trends Cogn Sci. 2022 Oct 24:S1364-6613(22)00238-8. doi: 10.1016/j.tics.2022.09.017. Online ahead of print

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Kalisch R, Köber G, Binder H, Ahrens KF, Basten U, Chmitorz A, Choi KW, Fiebach CJ, Goldbach N, Neumann RJ, Kampa M, Kollmann B, Lieb K, Plichta MM, Reif A, Schick A, Sebastian A, Walter H, Wessa M, Yuen KSL, Tüscher O, Engen H (2021). The Frequent Stressor and Mental Health Monitoring-Paradigm: A Proposal for the Operationalization and Measurement of Resilience and the Identification of Resilience Processes in Longitudinal Observational Studies. Front Psychol. 12:710493.

>> Link zu Pubmed

Köber G, Kalisch R, Puhlmann L, Chmitorz A, Schick A,  Binder H (2021) Deep learning and differential equations for modeling changes in individual-level latent dynamics between observation periods. Biometrical Journal. 52. In press

>> Link zu Pubmed

Veer et al (2021) Psycho-social factors associated with mental resilience in the Corona lockdown. Transl Psychiatry 11:67.

>> Link zu Pubmed

Ungar M et al (2021) Multisystemic Resilience: Adaptation and Transformation in Contexts of Change

>> Link zum Artikel

Chmitorz A, Kurth K, Mey LK, Wenzel M, Lieb K, Tüscher O, Kubiak T, Kalisch R (2020). Assessment of microstressors in adults: Questionnaire development and ecological validation of the Mainz Inventory of Microstressors. JMIR Ment Health 7(2):e14566.

>> Link zu Pubmed

Kampa M, Schick A, Sebastian A, Wessa M, Tüscher O, Kalisch R, Yuen K (2020). Replication of fMRI group activations in the neuroimaging battery for the Mainz Resilience Project (MARP). Neuroimage 204:116223.

>> Link zu Pubmed

Kalisch R, Gerlicher AMV, Duvarci S (2019) A Dopaminergic Basis for Fear Extinction. Trends Cogn Sci 23:274-7.

>> Link zu Pubmed

Gerlicher AMV, Tüscher O, Kalisch R. Dopamine-dependent prefrontal reactivations explain long-term benefit of fear extinction. Nat Commun. 2018 Oct 16;9(1):4294. doi: 10.1038/s41467-018-06785-y. Erratum in: Nat Commun. 2019 Jan 23;10(1):471. doi: 10.1038/s41467-019-08399-4. PMID: 30327462; PMCID: PMC6191435.

>> Link zu Pubmed

Salinas-Hernández XI, Vogel P, Betz S, Kalisch R, Sigurdsson T, Duvarci S. Dopamine neurons drive fear extinction learning by signaling the omission of expected aversive outcomes. Elife. 2018 Nov 13;7:e38818. doi: 10.7554/eLife.38818. PMID: 30421719; PMCID: PMC6257816.

>> Link zu Pubmed

Kalisch R, Baker DG, Basten U, Boks MP, Bonanno GA, Brummelman E, Chmitorz A, Fernàndez G, Fiebach CJ, Galatzer-Levy I, Geuze E, Groppa S, Helmreich I, Hendler T, Hermans EJ, Jovanovic T, Kubiak T, Lieb K, Lutz B, Müller MB, Murray RJ, Nievergelt CM, Reif A, Roelofs K, Rutten BPF, Sander D, Schick A, Tüscher O, Van Diest I, van Harmelen AL, Veer IM, Vermetten E, Vinkers CH, Wager TD, Walter H, Wessa M, Wibral M, Kleim B (2017) The resilience framework as a strategy to combat stress-related disorders. Nat Hum Behav 1:784−790.

>> Link zu Pubmed

Kalisch R, Müller MB, Tüscher O (2015) A conceptual framework for the neurobiological study of resilience. Behav Brain Sci 27:1−79

>> Link zu Pubmed

Haaker J, Gaburro S, Sah A, Gartmann N, Lonsdorf TB, Meier K, Singewald N, Pape HC, Morellini F*, Kalisch R* (2013) Single dose of L-DOPA makes extinction memories context-independent and prevents the return of fear. Proc Natl Acad Sci USA 110:E2428−E2436. *equal contribution

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Raczka KA, Mechias ML, Gartmann N, Reif A, Deckert J, Pessiglione M, Kalisch R. Empirical support for an involvement of the mesostriatal dopamine system in human fear extinction. Transl Psychiatry. 2011 Jun 7;1(6):e12. doi: 10.1038/tp.2011.10. PMID: 22832428; PMCID: PMC3309464.

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Etkin A, Egner T, Kalisch R (2011) Emotional processing in anterior cingulate and medial prefrontal cortex. Trends Cogn Sci 15:85−93.

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Raczka KA, Gartmann N, Mechias ML, Reif A, Buchel C, Deckert J, Kalisch R (2010) A neuropeptide S receptor variant associated with overinterpretation of fear reactions: a potential neurogenetic basis for catastrophizing. Mol Psychiatry 15:1067−1074. Corrigendum: 17:468.

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Kalisch R (2009) The functional neuroanatomy of reappraisal: time matters. Neurosci Biobehav Rev 33:1215-26.

>> Link zu Pubmed

Pessiglione M, Schmidt L, Draganski B, Kalisch R, Lau H, Dolan RJ, Frith CD (2007) How the brain translates money into force: a neuroimaging study of subliminal motivation. Science 316:904−906.

>> Link zu Pubmed
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