Verstanden

Prof. Dr. Susann Schweiger

Research Group Leader LIR, Director of Institute for Human Genetics University Medical Center of the Johannes Gutenberg-University Mainz, Professor for Human Genetics

Kontakt

Leibniz-Institut für Resilienzforschung gGmbH
Langenbeckstraße 1
55131 Mainz

+49 (0)6131 17-5788
Expertise
General Information
Year of Birth

1970

Current Position

Research Group Leader, Leibniz Institute for Resilience Research (LIR), Mainz, Germany Professor for Human Genetics, Director of Institute for Human Genetics, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany

University training and degrees
11/2006

Board certification Human Genetics, Ärztekammer Berlin, Germany

1999 – 2004

Residency training Human Genetics, Charité University Medicine Berlin, Germany

08/2005 – 02/2006

Registrar: Department of Dermatology, Charité University Medicine Berlin, Germany, Full registration, Ärztekammer Hamburg, Germany

07/1994 – 06/1995

Registrar: Department of Pharmacology, University Hospital FU Berlin, Germany

10/1993 – 06/1994

Registrar: Department of Internal Medicine, University Hospital Hamburg, Germany

10/1993

Provisional registration, Ärztekammer Hamburg, Germany

10/1993

Dr. med. (M.D.); Innsbruck Medical School, Austria 10/1993; Graduation; Innsbruck Medical School, Austria

10/1987 – 10/1993

Undergraduate Training; Innsbruck Medical School, Austria

Advanced academic qualifications
10/1993

Dr. med. (M.D.); Innsbruck Medical School, Austria 10/1993; Graduation; Innsbruck Medical School, Austria

Postgraduate professional career
Since 01/2020

Research Group Leader at the Leibniz Institute for Resilience Research (LIR), Mainz, Germany

Since 01/2018

Research Group Leader at the German Resilience Center (DRZ) Mainz, Germany

Since 09/2012

Professor for Human Genetics, University Medical Center of the Johannes Gutenberg University Mainz, Germany

Director Institute for Human Genetics, University Medical Center of the Johannes Gutenberg University Mainz, Germany

08/2007 – 08/2012

Professor for Molecular Medicine, Ninewells Hospital, Dundee, Scotland, United Kingdom

Academic Lead of the Department for Human Genetics

05/2010 – 08/2012

Deputy Head of the Wellcome Trust Centre for Molecular Medicine

08/2008 – 05/2010

Head of the Centre for Oncology and Molecular Medicine

04/2005 – 08/2007

Lichtenberg Professor for Clinical and Molecular Genetics, Charité University Medicine, Berlin, Germany

1990 – 1992

M.D.-Ph.D. thesis: Institute of Organic Chemistry and Biochemistry, Freiburg, Germany; “Purification, characterization and crystallization of the membrane protein Maltoporin, the membrane-associated proteins Adrenodoxin Reduktase, and the tissue-plasminogene activator tPA” (supervisor: Georg E. Schulz, University of Freiburg, Germany)

Other professional activities or honors
2005 – 2010

Lichtenberg professorship of the “Volkswagenstiftung”

1995 – 1997

Research grant of the Max Planck Society

1987 – 1993

Member of the “Studienstiftung des Deutschen Volkes”

 

Selected Publications

Arnoux I, Willam M, Griesche N, Krummeich J, Watari H, Offermann N, Weber S, Narayan Dey P, Chen C, Monteiro O, Buettner S, Meyer K, Bano D, Radyushkin K, Langston R, Lambert JJ, Wanker E, Methner A, Krauss S, Schweiger S, Stroh A (2018) Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease. eLife 7:e38744. doi: 10.7554/eLife.38744.

>> Link zu Pubmed

Schweiger S, Matthes F, Posey K, Kickstein E, Weber S, Hettich MM, Pfurtscheller S, Ehninger D, Schneider R, Krauß S (2017) Resveratrol induces de-phosphorylation of tau by interfering with the MID1-PP2A complex. Sci Rep 7(1):13753. doi: 10.1038/s41598-017-12974-4.

>> Link zu Pubmed

Schweiger S, Dorn S, Fuchs M, Köhler A, Matthes F, Müller EC, Wanker E, Schneider R, Krauß S (2014) The E3-ubiquitin ligase MID1 catalyzes ubiquitination and cleavage of Fu. J Biol Chem 289(46):31805–17. doi: 10.1074/jbc.M113.541219.

>> Link zu Pubmed

Krauss S, Griesche N, Jastrzebska E, Chen C, Rutschow D, Achmüller C, Dorn S, Boesch SM, Lalowski M, Wanker E, Schneider R, Schweiger S (2013) Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex. Nat Commun 4:1511. doi: 10.1038/ncomms2514.

>> Link zu Pubmed

Aranda-Orgilles B, Rutschow D, Zeller R, Karagiannidis AI, Köhler A, Chen C, Wilson T, Krause S, Roepcke S, Lilley D, Schneider R, Schweiger S (2011) Protein phosphatase 2A (PP2A)-specific ubiquitin ligase MID1 is a sequence-dependent regulator of translation efficiency controlling 3-phosphoinositide-dependent protein kinase-1 (PDPK-1). J Biol Chem 286:39945–39957.

>> Link zu Pubmed

Liu E, Knutzen CA, Krauss S, Schweiger S, Chiang GG (2011) Control of mTORC1 signaling by the Opitz syndrome protein MID1. Proc Natl Acad Sci USA 108:8680–8685.

>> Link zu Pubmed

Kickstein E, Krauss S, Thornhill P, Rutschow D, Zeller R, Sharkey J, Williamson R, Fuchs M, Köhler A, Glossmann H, Schneider R, Sutherland C, Schweiger S (2010) Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling. Proc Natl Acad Sci USA 107:21830–21835.

>> Link zu Pubmed

Krauß S, Foerster J, Schneider R, Schweiger S (2008) Protein phosphatase 2A and rapamycin regulate the nuclear localization and activity of the transcription factor GLI3. Cancer Res 68(12):4658–4665.

>> Link zu Pubmed

Kalscheuer VM, Freude K, Musante L, Jensen LR, Yntema HG, Gécz J, Sefiani A, Hoffmann K, Moser B, Haas S, Gurok U,Haesler S, Aranda B, Nshedjan A, Tzschach A, Hartmann N, Roloff TC, Shoichet S, Hagens O, Tao J, van Bokhoven H, Turner G, Chelly J, Moraine C, Fryns JP, Nuber U, Hoeltzenbein M, Scharff C, Scherthan H, Lenzner S, Hamel BCJ, Schweiger S, Ropers HH (2003) Mutations in the polyglutamine binding protein 1 gene cause X-linked mental retardation. Nat Genet 35(4):313–315.

>> Link zu Pubmed

Trockenbacher A, Suckow V, Foerster J, Winter J, Krauß S, Ropers HH, Schneider R, Schweiger S (2001) MID1, mutated in Opitz syndrome, encodes an ubiquitin ligase that targets phosphatase 2A for degradation. Nat Genet 29:287–294.

>> Link zu Pubmed
Kontakt
Leibniz-Institut für Resilienzforschung (LIR) gGmbH
Wallstraße 7
55122 Mainz
Telefon: +49 (0)6131 17-5788
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