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Clinical Investigation Center (CIC)

Short description of the platform

Head: Prof. Dr Oliver Tüscher

Staff members:

  • Charlotte Dörschner, Scientific Staff

  • Dr. Bianca Kollmann

  • Danuta Weichert, Study Coordinator

The central role of the Clinical Investigation Center (CIC) within the LIR is to conduct human resilience studies. The focus is on the longitudinal measurement of mental and psychophysiological outcome measures, since this is the only way to achieve assessments and quantifications of resilience in human studies (Kalisch et al., 2015). The CIC is also the central organizational and recruiting framework for all human studies in the LIR. This central function is achieved in particular through the implementation of the Gutenberg Brain Study (GBS) and the associated (satellite) studies. The CIC recruits and characterizes all subjects/people who are included in later LIR projects. Since resilience factors against everyday stressors and their connection with putative resilience mechanisms have not been systematically investigated, the CIC initiates a register-based longitudinal study that is anchored in the GBS (Mainz Resilience Factors in Everyday Life, MARF). For this purpose, the CIC establishes methods of the most modern, ecologically valid momentary assessment and intervention technology (AA and EMA/EMI) for the LIR. As another important function for the LIR, the CIC will implement and conduct intervention studies, including psychological training programs, pharmacological studies or neurotechnical interventions (e.g., neurofeedback, transcranial stimulation). The CIC acts as the central executive platform of the LIR, translating the research results of the research department A-D into human studies.

Current research projects:

  • Resilience-focused evaluation of the data from the Gutenberg Brain Study (GBS)

  • Supervision of the GBS satellite studies Implementation of the human PRG-1 studies

  • Resilience and political participation

  • Establishment of ecologically valid momentary assessment and intervention technology (AA and EMA/EMI)

  • Support for the central, longitudinal resilience studies MARP and LORA

  • Development of innovative non-invasive brain stimulation procedures and pharmacological interventions to promote resilience

  • Implementation of a long-term study to assess resilience and to study resilience factors (MARF)

Externe Kooperationspartner:

  • Prof. Dr Ines Germeys, Department of Neurosciences, KU Leuven, Belgium

  • Prof. Dr Hans Grabe, Klinik für Psychiatrie und Psychotherapie, University of Greifswald, Germany

  • Prof. Dr Martin Lotze, Baltic Neuroimaging Center, University of Greifswald, Germany

  • Prof. Dr Dr Henrik Walter, Klinik für Psychiatrie und Psychotherapie, Humboldt University, Charité, Berlin, Germany