RG Kalisch

Lead:
Prof. Dr Raffael Kalisch

Research Group Leader LIR, Director of Neuroimaging Center Mainz, Professor of Human Neuroimaging

Staff

Elena Andres, PhD student

Manuela Götz, Study Psychologist

Chuan-Peng Hu, Postdoc

Dr. Benjamin Meyer, Postdoc

Melike Kocak, Coordinator of MARP

Petra Seyfarth, Technician

Martina Thiele, PhD student

Dr. Kenneth S.L. Yuen, Postdoc

Anna Müller

Dirk Klasner

Jana Meier

Research group description

We investigate basic mechanisms of human resilience on a cognitive and neurofunctional level and strive to formulate a comprehensive and unifying theory of resilience. We use a dynamic term of resilience, which defines resilience as the result of an adaptation process to stressors. Important instruments are therefore prospective longitudinal studies (MARP), in which changes in biological and psychological functions are observed over time and depending on stress exposure and their importance for the maintenance of mental health are considered. Another important tool is the computer-aided analysis and modeling of these data sets and the associated mathematical formalization of the resilience theory. In addition, we use experimental psychology, brain imaging (MRI), brain stimulation (tDCS), pharmacology, and psychophysiology methods to carry out laboratory studies on the cognitive and neural basis of identified resilience mechanisms such as extinction and cognitive emotion regulation.

Current research projects

Longitudinal study: Mainz Resilience Project (MARP)
Dynamic Modelling of Resilience (DynaMORE)
Finding the good in the bad: fear extinction as an appetizing learning process
Role of spontaneous activity in a meso-prefontal circuit in the long-term consolidation of the extinction memory
Establishment of an ecologically valid trauma model for resilience research
Configuration and reconfiguration of trauma memories
Development of instruments for dynamic system analysis in resilience research (IDSAIR)

External cooperation partners

Prof. Dr Harald Binder, Institute of Medical Biometriy and Statistics (IMBI), Medical Center - University of Freiburg, Germany
Prof. Dr Angélique O. J. Cramer, Department of Methodology and Statistics, University of Tilburg, the Netherlands
Sevil Duvarci, PhD, Institute for Neurophysiology, Goethe University Frankfurt, Germany
Prof. Dr Guillén Fernàndez, Donders Institute, Radboud University Nijmegen, the Netherlands
Prof. Dr Talma Hendler, Functional Brain Center, University of Tel Aviv, Israel
Dr Erno Hermans, Donders Institute, Radboud University Nijmegen, the Netherlands
Prof. Dr Birgit Kleim, Clinic for Psychiatry, University of Zurich, Switzerland
Prof. Dr Karin Roelofs, Donders Institute, Radboud University Nijmegen, the Netherlands
Prof. Dr Jens Timmer, Institute for Physics, University of Freiburg, Germany
Prof. Dr Dr Henrik Walter, Clinic for Psychiatry, Humboldt University, Charité, Berlin, Germany

Sponsorships

German Research Foundation (DFG)
Boehringer Ingelheim Foundation
EU (Horizon 2020)
MWWK

Key Publications

Kampa M, Schick A, Sebastian A, Wessa M, Tüscher O, Kalisch R, Yuen K (2020). Replication of fMRI group activations in the neuroimaging battery for the Mainz Resilience Project (MARP). Neuroimage 204:116223. doi: 10.1016/j.neuroimage.2019.116223.

>> Link to Pubmed

Chmitorz A, Kurth K, Mey LK, Wenzel M, Lieb K, Tüscher O, Kubiak T, Kalisch R (2020). Assessment of microstressors in adults: Questionnaire development and ecological validation of the Mainz Inventory of Microstressors. JMIR Ment Health 7(2):e14566. doi: 10.2196/14566.

Gerlicher AMV, Tüscher O, Kalisch R (2019). L-DOPA improves extinction memory retrieval after successful fear extinction. Psychopharmacology (Berl) 236(12):3401-3412. doi: 10.1007/s00213-019-05301-4

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Meyer B, Mann C, Götz M, Gerlicher A, Saase V, Yuen KSL, Aedo-Jury F, Gonzalez-Escamilla G, Stroh A, Kalisch R (2019). Increased Neural Activity in Mesostriatal Regions after Prefrontal Transcranial Direct Current Stimulation and l-DOPA Administration. J Neurosci 39(27):5326-5335. doi: 10.1523/JNEUROSCI.3128-18.2019

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Kalisch R, Gerlicher AMV, Duvarci S (2019). A Dopaminergic Basis for Fear Extinction. Trends Cogn Sci 23(4):274-277. doi: 10.1016/j.tics.2019.01.013.

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Gottschalk MG, Richter J, Ziegler C, Schiele MA, Mann J, Geiger MJ, Schartner C, Homola GA, Alpers GW, Büchel C, Fehm L, Fydrich T, Gerlach AL, Gloster AT, Helbig-Lang S, Kalisch R, Kircher T, Lang T, Lonsdorf TB, Pané-Farré CA, Ströhle A, Weber H, Zwanzger P, Arolt V, Romanos M, Wittchen HU, Hamm A, Pauli P, Reif A, Deckert J, Neufang S, Höfler M, Domschke K (2019). Orexin in the anxiety spectrum: association of a HCRTR1 polymorphism with panic disorder/agoraphobia, CBT treatment response and fear-related intermediate phenotypes. Transl Psychiatry 9(1):75. doi: 10.1038/s41398-019-0415-8

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Gerlicher AMV, Tüscher O, Kalisch R (2018). Dopamine-dependent prefrontal reactivations explain long-term benefit of fear extinction. Nat Commun 9(1):4294. doi: 10.1038/s41467-018-06785-y. Erratum in: Nat Commun. 2019 Jan 23;10(1):471.

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Kleim B, Kalisch R (2018). [Who stays healthy? The problem of predicting resilience]. Nervenarzt 89(7):754-758. doi: 10.1007/s00115-018-0551-z. Review. German.

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Lindert J, Schick A, Reif A, Kalisch R, Tüscher O (2018). [Resilience trajectories-examples from longitudinal studies]. Nervenarzt 89(7):759-765. doi: 10.1007/s00115-018-0536-y. Review. German.

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Kunzler AM, Gilan DA, Kalisch R, Tüscher O, Lieb K (2018). [Current concepts of resilience research]. Nervenarzt 89(7):747-753. doi: 10.1007/s00115-018-0529-x. Review. German.

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Chmitorz A, Wenzel M, Stieglitz RD, Kunzler A, Bagusat C, Helmreich I, Gerlicher A, Kampa M, Kubiak T, Kalisch R, Lieb K, Tüscher O (2018). Population-based validation of a German version of the Brief Resilience Scale. PLoS One 13(2):e0192761. doi: 10.1371/journal.pone.0192761.

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Kalisch R, Baker DG, Basten U, Boks MP, Bonanno GA, Brummelman E, Chmitorz A, Fernàndez G, Fiebach CJ, Galatzer-Levy I, Geuze E, Groppa S, Helmreich I, Hendler T, Hermans EJ, Jovanovic T, Kubiak T, Lieb K, Lutz B, Müller MB, Murray RJ, Nievergelt CM, Reif A, Roelofs K, Rutten BPF, Sander D, Schick A, Tüscher O, Diest IV, Harmelen AV, Veer IM, Vermetten E, Vinkers CH, Wager TD, Walter H, Wessa M, Wibral M, Kleim B (2017). The resilience framework as a strategy to combat stress-related disorders. Nat Hum Behav 1(11):784-790. doi: 10.1038/s41562-017-0200-8

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Kalisch R, Müller MB, Tüscher O (2015). Advancing empirical resilience research. Behav Brain Sci 38:e128. doi: 10.1017/S0140525X1500002

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Kalisch R, Müller MB, Tüscher O (2015). A conceptual framework for the neurobiological study of resilience. Behav Brain Sci ;38:e92. doi: 10.1017/S0140525X1400082X

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