RG Kalisch
Lead:
RG Kalisch
Research Group Leader LIR, Director of Neuroimaging Center Mainz, Professor of Human Neuroimaging
Elena Andres, PhD student
Manuela Götz, Study psychologist
Kerstin Klein, Study assistant
Maximilian Lückel, PhD student
Dr Benjamin Meyer, Postdoc
Papoula Petri-Romao, PhD student
Lara Puhlmann, PhD student
Mona Ülker, Study assistant
Dr Kenneth S.L. Yuen, Postdoc
We investigate basic mechanisms of human resilience on a cognitive and neurofunctional level and strive to formulate a comprehensive and unifying theory of resilience. We use a dynamic conceptualization of resilience as resulting from processes of adaptation to stressors. Important instruments are prospective longitudinal studies (MARP, LORA, DynaM-OBS), in which changes in biological and psychological functions are observed over time and related to stressor exposure and changes in mental health. Another important tool is the computer-aided analysis and modeling of these data sets. Further, we use methods of experimental psychology, psychophysiology, brain imaging (MRI), neurostimulation (TMS), and psychopharmacology to carry out laboratory studies on the cognitive and neural basis of identified resilience mechanisms, such as extinction and volitional emotion regulation.
- Longitudinal study "Longitudinal Resilience Assessment" (LORA)
- Longitudinal study "Mainz Resilience Project" (MARP)
- Consortium project "Dynamic Modelling of Resilience" (DynaMORE)
- Consortium project "Improving the Preparedness of Health Systems to Reduce Mental Health and Psychosocial Concerns resulting from the COVID-19 Pandemic" (RESPOND)
- SFB1193 Subproject "Role of spontaneous activity in a meso-prefontal circuit in the long-term consolidation of the extinction memory"
- Establishment of an ecologically valid trauma model for resilience research
- Configuration and reconfiguration of trauma memories
- Harald Binder, Institute for Medical Biometry and Informatics, University of Freiburg, Germany
- Richard Bryant, School of Psychology, University of New South Wales, Sydney, Australia
- Angélique O.J. Cramer, Department of Methodology and Statistics, Tilburg University, Netherlands
- Sevil Duvarci, Institute for Neurophysiology, Goethe-University Frankfurt, Germany
- Guillén Fernàndez, Donders Institute, Radboud University Nijmegen, Netherlands
- Isaac Galatzer-Levy, AiCure, New York, United States
- Talma Hendler, Functional Brain Center, Tel Aviv University, Israel
- Erno Hermans, Donders Institute, Radboud University Nijmegen, Netherlands
- Birgit Kleim, Department of Psychiatry, University of Zurich, Switzerland
- Inez Myin-Germeys, Contextual Psychiatry, Catholic University Leuven, Belgium
- Andreas Reif, Department of Psychiatry and Psychotherapy, University Hospital, Goethe University Frankfurt a.M., Germany
- Karin Roelofs, Donders Institute, Radboud University Nijmegen, Netherlands
- Jens Timmer, Institute for Physics, University of Freiburg, Germany
- Marit Sijbrandij, Faculty of Behavioural and Movement Sciences, Clinical Psychology, Free University of Amsterdam, Netherlands
- Anne-Laura van Harmelen, Department of Psychiatry, University of Cambridge, UK
- Henrik Walter, Department of Psychiatry, Charité Berlin, Germany
- German Research Foundation (DFG)
- Boehringer Ingelheim Foundation
- EU (Horizon 2020)
- MWWK
Thiele M, Yuen KSL, Gerlicher AVM, Kalisch R (2021) A ventral striatal prediction error signal in human fear extinction learning. Neuroimage 229:117709.
>> Link to PubmedVeer et al (2021) Psycho-social factors associated with mental resilience in the Corona lockdown. Transl Psychiatry 11:67
>> Link to PubmedUngar M et al (2021) Multisystemic Resilience: Adaptation and Transformation in Contexts of Change
>> Link to articleKalisch R et al (preprint) A generic solution for the operationalization and measurement of resilience and resilience processes in longitudinal observations: rationale and basic design of the MARP and LORA studies. PsyArXiv (psyarxiv.com/jg238/)
Kampa M, Schick A, Sebastian A, Wessa M, Tüscher O, Kalisch R, Yuen K (2020). Replication of fMRI group activations in the neuroimaging battery for the Mainz Resilience Project (MARP). Neuroimage 204:116223. doi: 10.1016/j.neuroimage.2019.116223.
>> Link to PubmedChmitorz A, Kurth K, Mey LK, Wenzel M, Lieb K, Tüscher O, Kubiak T, Kalisch R (2020). Assessment of microstressors in adults: Questionnaire development and ecological validation of the Mainz Inventory of Microstressors. JMIR Ment Health 7(2):e14566. doi: 10.2196/14566.
>> Link to PubmedKalisch R*, Cramer AOJ*, Binder H, Fritz J, Leertouwer IJ, Lunansky G, Meyer B, Timmer J, Veer IM, van Harmelen A-L (2019) Deconstructing and reconstructing resilience: a dynamic network Approach. Persp Psych Sci, 14:765-7.
>> Link to PubmedKalisch R, Gerlicher AMV, Duvarci S (2019). A Dopaminergic Basis for Fear Extinction. Trends Cogn Sci 23(4):274-277. doi: 10.1016/j.tics.2019.01.013.
>> Link to PubmedGerlicher AMV, Tüscher O, Kalisch R (2018). Dopamine-dependent prefrontal reactivations explain long-term benefit of fear extinction. Nat Commun 9(1):4294. doi: 10.1038/s41467-018-06785-y. Erratum in: Nat Commun. 2019 Jan 23;10(1):471.
>> Link to PubmedChmitorz A, Wenzel M, Stieglitz RD, Kunzler A, Bagusat C, Helmreich I, Gerlicher A, Kampa M, Kubiak T, Kalisch R, Lieb K, Tüscher O (2018). Population-based validation of a German version of the Brief Resilience Scale. PLoS One 13(2):e0192761. doi: 10.1371/journal.pone.0192761.
>> Link to PubmedSalinas-Hernández XI, Vogel P, Betz S, Kalisch R, Sigurdsson T, Duvarci S (2018) Dopamine neurons drive fear extinction learning by signaling the omission of expected aversive Outcomes Elife7, pii: e38818. doi: 10.7554/eLife.38818.
>> Link to PubmedKalisch R, Baker DG, Basten U, Boks MP, Bonanno GA, Brummelman E, Chmitorz A, Fernàndez G, Fiebach CJ, Galatzer-Levy I, Geuze E, Groppa S, Helmreich I, Hendler T, Hermans EJ, Jovanovic T, Kubiak T, Lieb K, Lutz B, Müller MB, Murray RJ, Nievergelt CM, Reif A, Roelofs K, Rutten BPF, Sander D, Schick A, Tüscher O, Diest IV, Harmelen AV, Veer IM, Vermetten E, Vinkers CH, Wager TD, Walter H, Wessa M, Wibral M, Kleim B (2017). The resilience framework as a strategy to combat stress-related disorders. Nat Hum Behav 1(11):784-790. doi: 10.1038/s41562-017-0200-8
>> Link to PubmedKalisch R, Müller MB, Tüscher O (2015). Advancing empirical resilience research. Behav Brain Sci 38:e128. doi: 10.1017/S0140525X1500002
>> Link to PubmedKalisch R, Müller MB, Tüscher O (2015). A conceptual framework for the neurobiological study of resilience. Behav Brain Sci ;38:e92. doi: 10.1017/S0140525X1400082X
>> Link to PubmedHaaker J, Gaburro S, Sah A, Gartmann N, Lonsdorf TB, Meier K, Singewald N, Pape HC, Morellini F*, Kalisch R* (2013) Single dose of L-dopa makes extinction memories context-independent and prevents the return of fear. PNAS 110:E2428-36
>> Link to PubmedEtkin A, Egner T, Kalisch R (2011) Emotional processing in anterior cingulate and medial prefrontal cortex. Trends Cogn Sci 15:85-93.
>> Link to PubmedRaczka KA, Mechias ML, Gartmann N, Reif A, Deckert J, Pessiglione M, Kalisch R (2011) Empirical support for an involvement of the mesostriatal dopamine system in human fear extinction. Transl Psychiatry 1:e12.
>> Link to PubmedKalisch R (2009) The functional neuroanatomy of reappraisal: time matters. Neurosci Biobehav Rev 33:1215-26.
>> Link to PubmedKalisch R, Korenfeld E, Stephan KE, Weiskopf N, Seymour B, Dolan RJ (2006) Context-dependent human extinction memory is mediated by a ventromedial prefrontal and hippocampal network. J Neurosci 26:9503-11
>> Link to Pubmed