RG Lieb

Prof. Dr Klaus Lieb

Scientific Managing Director LIR, Professor for Psychiatry and Psychotherapy University Medical Center of the Johannes Gutenberg-University Mainz


Angela Kunzler, PhD student

Gesche Janzarik, PhD student

Lara Hubenschmid, PhD student

Manpreet Blessin, PhD student

Sophie Walter, PhD student

Research group description

The research group works on three topics:

1) Using the methods of the Cochrane Collaboration to create systematic reviews and meta-analyzes on resilience mechanisms and interventions that promote resilience, thus offering a knowledge platform for LIR staff and external scientists.

2) It develops psychotherapeutic, pharmacological, and other methods for promoting resilience on the basis of resilience mechanisms that are investigated in our long-term studies and in cooperation with other working groups of the LIR. This includes closed-loop neurostimulation procedures, sports and online psychotherapy programs.

3) It critically reflects the ethical and theoretical implications of the resilience concept and the effects of resilience-promoting measures and examines the effects of pharmacological cognitive enhancement on individual resilience.

Current research projects
  • Resilience factors in diachronic and intercultural perspectives - What makes people resilient?
  • Systematic reviews and meta-analyses of effective resilience interventions in co-operation with the Cochrane Collaboration
  • Development of psychotherapeutic interventions to promote resilience, including online procedures
  • Development of innovative non-invasive brain stimulation methods and pharmacological interventions to promote resilience
  • Effects of pharmacological cognitive enhancement on resilience
  • Medical ethics and theory of resilience research
  • Development of a group psychotherapy program to promote resilience (The new growth)
  • Development of instruments for dynamic system analysis in resilience research (IDSAIR)
External cooperation partners
  • Prof. Dr Alexandra Busch, Römisch-Germanisches Zentralmuseum (RGZM), Leibniz Research Institute for Archaeology, Mainz
  • Prof. Dr Dr Andreas Franke, University of Applied Labour Studies, Mannheim
  • Prof. Dr Dirk Lehr, Leuphania University Lüneburg
  • Dr Geraldine MacDonald, Cochrane Collaboration, CDPLP Group, Bristol, United Kingdom
  • Prof. Dr Norbert Paul, Institute for History, Philosophy and Ethics of Medicine, Medical Center of the Johannes Gutenberg University Medical Center, Mainz
  • Prof. Dr Rolf van Dick, Social Psychology, Goethe University Frankfurt
  • Prof. Dr Ulf Ziemann, Neurology, Hertie Institute for Clinical Brain Research, Tübingen
  • BMBF
  • Boehringer Ingelheim Foundation
  • Leibniz Association (Kooperative Exzellenz)
  • Bundesministerium für Gesundheit/Federal Ministry of Health
  • MWWK
Key Publications

Ludolph, P., Kunzler, A., Stoffers-Winterling, J., Helmreich, I., Lieb, K., (2019). Resilienzfördernde Interventionen bei Patienten mit Krebs. Dtsch. Ärztebl. Int. 116:865-72

Bagusat C, Kunzler A, Schlecht J, Franke AG, Chmitorz A, Lieb K (2018) Pharmacological neuroenhancement and the ability to recover from stress – a representative cross-sectional survey among the German population. Substance Abuse Treatment, Prevention, and Policy 13(1)37. doi: 10.1186/s13011-018-0174-1

>> Link to Pubmed

Linz S, Helmreich I, Kunzler A, Chmitorz A, Lieb K, Kubiak T (2019) [Interventions To Promote Resilience In Adults - A Narrative Review]. Psychother Psychosom Med Psychol. doi: 10.1055/a-0830-4745.

>> Link to Pubmed

Chmitorz A*, Kunzler A*, Helmreich I, Tüscher O, Kalisch R, Kubiak T, Wessa M, Lieb K (2018) Intervention studies to foster resilience – a systematic review and proposal for a resilience framework in future intervention studies. Clin Psychol Rev 59:78-100. *Equal contr.

>> Link to Pubmed

Chmitorz A, Wenzel M, Stieglitz RD, Kunzler A, Bagusat C, Helmreich I, Gerlicher A, Kampa M, Kubiak T, Kalisch R, Lieb K, Tüscher O (2018) Population-based validation of a German version of the Brief Resilience Scale. PLoS One 13(2):e0192761. doi: 10.1371/journal.pone.0192761.

>> Link to Pubmed

Wagner S, Engel A, Engelmann J, Herzog D, Dreimüller N, Müller MB, Tadic A, Lieb K (2017) Early improvement as a resilience signal predicting later remission to antidepressant treatment in patients with Major Depressive Disorder: Systematic review and meta-analysis. J Psychiatr Res 94:96-106.

>> Link to Pubmed

Kalisch R, Baker DG, Basten U, Boks MP, Bonanno GA, Brummelman E, Chmitorz A, Fernàndez G, Fiebach CJ, Galatzer-Levy I, Geuze E, Groppa S, Helmreich I, Hendler T, Hermans EJ, Jovanovic T, Kubiak T, Lieb K, Lutz B, Müller MB, Murray RJ, Nievergelt CM, Reif A, Roelofs K, Rutten BPF, Sander D, Schick A, Tüscher O, Diest IV, Harmelen AV, Veer IM, Vermetten E, Vinkers CH, Wager TD, Walter H, Wessa M, Wibral M, Kleim B (2017). The resilience framework as a strategy to combat stress-related disorders. Nat Hum Behav 1(11):784-790. doi: 10.1038/s41562-017-0200-8

>> Link to Pubmed

Franke AG, Gränsmark P, Agricola A, Schühle K, Rommel T, Sebastian A, Balló HE, Gorbulev S, Gerdes C, Frank B, Ruckes C, Tüscher O, Lieb K (2017) Methylphenidate, modafinil, and caffeine for cognitive enhancement in chess: A double-blind, randomised controlled trial. Eur Neuropsychopharmacol 27(3):248-260.

>> Link to Pubmed

Helmreich I*, Kunzler A*, Chmitorz A, König J, Binder H, Wessa M, Lieb K (2017) Psychological interventions for resilience enhancement in adults. Cochrane Database Syst Rev Issue 2. Art. No.: CD012527. DOI: 10.1002/14651858.CD012527. *Equal contr.

>> Link to Pubmed

Franke AG, Roser P, Lieb K, Vollmann J, Schildmann J (2016) Cannabis for Cognitive Enhancement as a New Coping Strategy? Results From a Survey of Students at Four Universities in Germany. Subst Use Misuse 51(14):1856-62.

>> Link to Pubmed
Leibniz Institute for Resilience Research (LIR)
Wallstraße 7
55122 Mainz
Phone: +49 (0)6131 89448-77
Further Information