RG Lutz
Lead:
Prof. Dr Beat Lutz
Scientific Managing Director LIR, Professor and Director of Institute of Physiological Chemistry University Medical Center of the Johannes Gutenberg-University Mainz
Annika Beer, PhD student
Larglinda Islami, PhD student
Florian König, Technician
Verena Könning, Technician
Dr Inigo Ruiz de Azua, Postdoc
Dr. Margaryta Tevosian, Postdoc
Constance Vennin, Postdoc
Dr. Jingzhang Wei, Postdoc
The research group investigates the importance of the endocannabinoid system as a mediator of stress resilience. For this purpose, this neuromodulatory system is studied by genetic, epigenetic and pharmacological methods in mice. Not only brain functions with respect to stress resilience will be investigated, but also peripheral neuronal, hormonal and immunological mechanisms. Physical activity may also influence stress response and resilience. Studies of learning and memory and fear text induction will also be included, as these processes also affect stress resilience.
- Transcriptional network analyses in stress resilience using single-cell sequencing in selected neural cell populations in mice
- Description of neuronal activities during fear extinction
- Signaling mediators in blood to mediate stress resilience
- Endocannabinoids in the mediation of stress resilience
- Mapping activated brain regions in stress resilience
- Prof. Dr Rafael Maldonado, Department of Experimental and Health Sciences, University Pompeu Fabra, Barcelona, Spanien
- Dr. Giovanni Marsicano, INSERM Bordeaux, Frankreich
- Prof. Dr. Stefan Remy, LIN Magdeburg
- Prof. Dr. Dr. Michael Schmeißer, UM Mainz
- German Research Foundation (DFG)
- ERA-NET Neuron / BMBF
- Leibniz Alliance
Domingo-Rodriguez L, Ruiz de Azua I, Dominguez E, Senabre E, Serra I, Kummer S, Navandar M, Baddenhausen S, Hofmann C, Andero R, Gerber S, Navarrete M, Dierssen M, Lutz B, Martín-García E, Maldonado R (2020) A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction. Nat Commun 11:782. doi: 10.1038/s41467-020-14458-y
>> Link to PubmedJimenez-Blasco D, Busquets-Garcia A, Hebert-Chatelain E, Serrat R, Vicente-Gutierrez C, Ioannidou C, Gómez-Sotres P, Lopez-Fabuel I, Resch-Beusher M, Resel E, Arnouil D, Saraswat D, Varilh M, Cannich A, Julio-Kalajzic F, Bonilla-Del Río I, Almeida A, Puente N, Achicallende S, Lopez-Rodriguez ML, Jollé C, Déglon N, Pellerin L, Josephine C, Bonvento G, Panatier A, Lutz B, Piazza PV, Guzmán M, Bellocchio L, Bouzier-Sore AK, Grandes P, Bolaños JP, Marsicano G (2020) Glucose metabolism links astroglial mitochondria to cannabinoid effects. Nature. 583:603-608. doi: 10.1038/s41586-020-2470-y
>> Link to PubmedSuárez J, Rivera P, Aparisi Rey A, Pérez-Martín M, Arrabal S, Rodríguez de Fonseca F, Ruiz de Azua I, Lutz B (2019) Adipocyte cannabinoid CB1 receptor deficiency alleviates high fat diet-induced memory deficit, depressive-like behavior, neuroinflammation and impairment in adult neurogenesis. Psychoneuroendocrinology 110:104418. doi: 10.1016/j.psyneuen.2019.104418
>> Link to PubmedRuiz de Azua I, Lutz B (2019) Multiple endocannabinoid-mediated mechanisms in the regulation of energy homeostasis in brain and peripheral tissues. Cell Mol Life Sci 76(7):1341-1363. doi: 10.1007/s00018-018-2994-6.
>> Link to PubmedZimmermann T, Bartsch JC, Beer A, Lomazzo E, Guggenhuber S, Lange MD, Bindila L, Pape HC, Lutz B (2019) Impaired anandamide/palmitoylethanolamide signaling in hippocampal glutamatergic neurons alters synaptic plasticity, learning, and emotional responses. Neuropsychopharmacology 44(8):1377-1388. doi: 10.1038/s41386-018-0274-7
>> Link to PubmedRivera P, Silva-Peña D, Blanco E, Vargas A, Arrabal S, Serrano A, Pavón FJ, Bindila L, Lutz B, Rodríguez de Fonseca F, Suárez J (2019) Oleoylethanolamide restores alcohol-induced inhibition of neuronal proliferation and microglial activity in striatum. Neuropharmacology 146:184-197. doi: 10.1016/j.neuropharm.2018.11.037.
>> Link to PubmedZimmermann T, Maroso M, Beer A, Baddenhausen S, Ludewig S, Fan W, Vennin C, Loch S, Berninger B, Hofmann C, Korte M, Soltesz I, Lutz B, Leschik J (2018) Neural stem cell lineage-specific cannabinoid type-1 receptor regulates neurogenesis and plasticity in the adult mouse hippocampus. Cereb Cortex 28(12):4454-4471. doi: 10.1093/cercor/bhy258.
>> Link to PubmedWickert M, Hildick KL, Baillie GL, Jelinek R, Aparisi Rey A, Monory K, Schneider M, Ross RA, Henley JM, Lutz B (2018) The F238L Point Mutation in the Cannabinoid Type 1 Receptor Enhances Basal Endocytosis via Lipid Rafts. Front Mol Neurosci 11:230. doi: 10.3389/fnmol.2018.00230.
>> Link to PubmedKalisch R, Baker DG, Basten U, Boks MP, Bonanno GA, Brummelman E, Chmitorz A, Fernàndez G, Fiebach CJ, Galatzer-Levy I, Geuze E, Groppa S, Helmreich I, Hendler T, Hermans EJ, Jovanovic T, Kubiak T, Lieb K, Lutz B, Müller MB, Murray RJ, Nievergelt CM, Reif A, Roelofs K, Rutten BPF, Sander D, Schick A, Tüscher O, Diest IV, Harmelen AV, Veer IM, Vermetten E, Vinkers CH, Wager TD, Walter H, Wessa M, Wibral M, Kleim B (2017) The resilience framework as a strategy to combat stress-related disorders. Nat Hum Behav (11):784-790. doi: 10.1038/s41562-017-0200-8.
>> Link to PubmedLange MD, Daldrup T, Remmers R, Szkudlarek HJ, Lesting J, Guggenhuber G, Ruehle S, Jüngling K, Seidenbecher T, Lutz B, Pape HC (2017) Cannabinoid CB1 receptors in distinct circuits of the extended amygdala determine fear responsiveness to unpredictable threat. Mol Psychiatry 22(10):1422-1430.
>> Link to PubmedRuiz de Azua I, Mancini G, Srivastava RK, Rey AA, Cardinal P, Tedesco L, Zingaretti CM, Sassmann A, Quarta C, Schwitter C, Conrad A, Wettschureck N, Vemuri VK, Makriyannis A, Hartwig J, Mendez-Lago M, Bindila L, Monory K, Giordano A, Cinti S, Marsicano G, Offermanns S, Nisoli E, Pagotto U, Cota D, Lutz B (2017) Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages. J Clin Invest 127:4148-4162. doi: 10.1172/JCI83626
>> Link to PubmedBusquets-Garcia A, Gomis-González M, Srivastava RK, Cutando L, Ortega-Alvaro A, Ruehle S, Remmers F, Bindila L, Bellocchio L, Marsicano G, Lutz B*, Maldonado R*, Ozaita A* (2016) Peripheral and central CB1 cannabinoid receptors control stress-induced impairment of memory consolidation. Proc Natl Acad Sci USA 113:9904-9. *shared senior authors
>> Link to PubmedFuss J, Steinle J, Bindila L, Auer MK, Kirchherr H, Lutz B, Gass P (2015) A runner's high depends on cannabinoid receptors in mice. Proc Natl Acad Sci USA 112:13105-8.
>> Link to PubmedLomazzo E, Bindila L, Remmers F, Lerner R, Schwitter C, Hoheisel U, Lutz B (2015) Therapeutic potential of inhibitors of endocannabinoid degradation for the treatment of stress-related hyperalgesia in an animal model of chronic pain. Neuropsychopharmacol 40:488-501.
>> Link to PubmedLutz B, Marsicano G, Maldonado R, Hillard CJ (2015) The endocannabinoid system in gating fear, anxiety and stress. Nat Rev Neurowsci 16:705-18.
>> Link to Pubmed