understood

RG Lutz



Lead:
Prof. Dr Beat Lutz

Scientific Managing Director LIR, Professor and Director of Institute of Physiological Chemistry University Medical Center of the Johannes Gutenberg-University Mainz

Staff

Constance Vennin, Postdoc

Florian König, Technician

Larglinda Islami, PhD student

Dr. Inigo Ruiz de Azua, Postdoc

Margaryta Tevosian, PhD student

Verena Könning, Technician

Research group description

The research group examines the importance of the endocannabinoid system as a mediator of stress resilience. For this purpose, this neuromodulatory system is examined in mice using genetic, epigenetic, and pharmacological methods. Not only brain functions regarding stress resilience are examined, but also peripheral neuronal, hormonal, and immunological mechanisms. Physical activity can also affect stress response and resilience. Those mechanisms are examined in the future. Addiction behavior and impulse control will also be included, and the question why only a small number of animals despite exposure to appetite-increasing food lose control over eating behavior will be investigated.

Current research projects
  • Transkriptionale Netzwerkanalysen in Stressresilienz mittels Einzelzell-Sequenzierungen in ausgewählten neuralen Zellpopulationen in der Maus
  • Signalmediatoren im Blut zur Vermittlung von trainingsinduzierter Stressresilienz
  • Endocannabinoide in der Vermittlung der Stressresilienz
  • Kartierung aktivierter Gehirnregionen in Stressresilienz
External cooperation partners
  • Prof. Dr Rafael Maldonado, Department of Experimental and Health Sciences, University Pompeu Fabra, Barcelona, Spanien
  • Prof. Dr Hans-Christian Pape, Institute of Physiology, University ofMünster
Sponsorships
  • German Research Foundation (DFG)
  • Boehringer Ingelheim Foundation
Key Publications

Domingo-Rodriguez L, Ruiz de Azua I, Dominguez E, Senabre E, Serra I, Kummer

S, Navandar M, Baddenhausen S, Hofmann C, Andero R, Gerber S, Navarrete M,

Dierssen M, Lutz B, Martín-García E, Maldonado R (2020) A specific prelimbic-nucleus

accumbens pathway controls resilience versus vulnerability to food addiction. Nat

Commun 11:782. doi: 10.1038/s41467-020-14458-y

>> Link to Pubmed

Suárez J, Rivera P, Aparisi Rey A, Pérez-Martín M, Arrabal S, Rodríguez de Fonseca F, Ruiz de Azua I, Lutz B (2019) Adipocyte cannabinoid CB1 receptor deficiency alleviates high fat diet-induced memory deficit, depressive-like behavior, neuroinflammation and impairment in adult neurogenesis. Psychoneuroendocrinology 110:104418. doi: 10.1016/j.psyneuen.2019.104418

>> Link to Pubmed

Ruiz de Azua I, Lutz B (2019) Multiple endocannabinoid-mediated mechanisms in the regulation of energy homeostasis in brain and peripheral tissues. Cell Mol Life Sci 76(7):1341-1363. doi: 10.1007/s00018-018-2994-6.

>> Link to Pubmed

Zimmermann T, Bartsch JC, Beer A, Lomazzo E, Guggenhuber S, Lange MD, Bindila L, Pape HC, Lutz B (2019) Impaired anandamide/palmitoylethanolamide signaling in hippocampal glutamatergic neurons alters synaptic plasticity, learning, and emotional responses. Neuropsychopharmacology 44(8):1377-1388. doi: 10.1038/s41386-018-0274-7

>> Link to Pubmed

Rivera P, Silva-Peña D, Blanco E, Vargas A, Arrabal S, Serrano A, Pavón FJ, Bindila L, Lutz B, Rodríguez de Fonseca F, Suárez J (2019) Oleoylethanolamide restores alcohol-induced inhibition of neuronal proliferation and microglial activity in striatum. Neuropharmacology 146:184-197. doi: 10.1016/j.neuropharm.2018.11.037.

>> Link to Pubmed

Zimmermann T, Maroso M, Beer A, Baddenhausen S, Ludewig S, Fan W, Vennin C, Loch S, Berninger B, Hofmann C, Korte M, Soltesz I, Lutz B, Leschik J (2018) Neural stem cell lineage-specific cannabinoid type-1 receptor regulates neurogenesis and plasticity in the adult mouse hippocampus. Cereb Cortex 28(12):4454-4471. doi: 10.1093/cercor/bhy258.

>> Link to Pubmed

Wickert M, Hildick KL, Baillie GL, Jelinek R, Aparisi Rey A, Monory K, Schneider M, Ross RA, Henley JM, Lutz B (2018) The F238L Point Mutation in the Cannabinoid Type 1 Receptor Enhances Basal Endocytosis via Lipid Rafts. Front Mol Neurosci 11:230. doi: 10.3389/fnmol.2018.00230.

>> Link to Pubmed

Kalisch R, Baker DG, Basten U, Boks MP, Bonanno GA, Brummelman E, Chmitorz A, Fernàndez G, Fiebach CJ, Galatzer-Levy I, Geuze E, Groppa S, Helmreich I, Hendler T, Hermans EJ, Jovanovic T, Kubiak T, Lieb K, Lutz B, Müller MB, Murray RJ, Nievergelt CM, Reif A, Roelofs K, Rutten BPF, Sander D, Schick A, Tüscher O, Diest IV, Harmelen AV, Veer IM, Vermetten E, Vinkers CH, Wager TD, Walter H, Wessa M, Wibral M, Kleim B (2017) The resilience framework as a strategy to combat stress-related disorders. Nat Hum Behav (11):784-790. doi: 10.1038/s41562-017-0200-8.

>> Link to Pubmed

Lange MD, Daldrup T, Remmers R, Szkudlarek HJ, Lesting J, Guggenhuber G, Ruehle S, Jüngling K, Seidenbecher T, Lutz B, Pape HC (2017) Cannabinoid CB1 receptors in distinct circuits of the extended amygdala determine fear responsiveness to unpredictable threat. Mol Psychiatry 22(10):1422-1430.

>> Link to Pubmed

Ruiz de Azua I, Mancini G, Srivastava RK, Rey AA, Cardinal P, Tedesco L,

Zingaretti CM, Sassmann A, Quarta C, Schwitter C, Conrad A, Wettschureck N,

Vemuri VK, Makriyannis A, Hartwig J, Mendez-Lago M, Bindila L, Monory K, Giordano

A, Cinti S, Marsicano G, Offermanns S, Nisoli E, Pagotto U, Cota D, Lutz B (2017)

Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively

activated macrophages. J Clin Invest 127:4148-4162. doi:

10.1172/JCI83626

>> Link to Pubmed

Busquets-Garcia A, Gomis-González M, Srivastava RK, Cutando L, Ortega-Alvaro A, Ruehle S, Remmers F, Bindila L, Bellocchio L, Marsicano G, Lutz B*, Maldonado R*, Ozaita A* (2016) Peripheral and central CB1 cannabinoid receptors control stress-induced impairment of memory consolidation. Proc Natl Acad Sci USA 113:9904-9. *shared senior authors

>> Link to Pubmed

Fuss J, Steinle J, Bindila L, Auer MK, Kirchherr H, Lutz B, Gass P (2015) A runner's high depends on cannabinoid receptors in mice. Proc Natl Acad Sci USA 112:13105-8.

>> Link to Pubmed

Lomazzo E, Bindila L, Remmers F, Lerner R, Schwitter C, Hoheisel U, Lutz B (2015) Therapeutic potential of inhibitors of endocannabinoid degradation for the treatment of stress-related hyperalgesia in an animal model of chronic pain. Neuropsychopharmacol 40:488-501.

>> Link to Pubmed

Lutz B, Marsicano G, Maldonado R, Hillard CJ (2015) The endocannabinoid system in gating fear, anxiety and stress. Nat Rev Neurowsci 16:705-18.

>> Link to Pubmed
Contact
Leibniz Institute for Resilience Research (LIR)
Wallstraße 7
55122 Mainz
Phone: +49 (0)6131 89448-77
Further Information