understood

RG Müller



Lead:
Prof. Dr Marianne Müller

Research Group Leader and Head of Mouse Behaviour Unit LIR, Professor for Psychiatry and Psychotherapy University Medical Center of the Johannes Gutenberg-University Mainz

Staff

Sarah Ayash, PhD, Postdoc

Dr. Esin Candemir, Postdoc

Verena Opitz, Lab Manager

Prof. Dr. Ulrich Schmitt, Scientific Staff

Giulia Treccani, PhD, Postdoc

Research group description

The aim of the research group is to contribute to an interdisciplinary team of doctors and scientists by translating clinically relevant questions into appropriate animal experimental models of basic research to develop improved, ideally causal treatment or prevention options for patients with mental illness. The working group works on two scientific goals by using a combination of behavioral biological, system physiological, and molecular analyzes.

1) The group develops and validates animal experimental models for resilience in order to use them to identify neurobiological mechanisms of resilience.

2) It examines the molecular mechanisms underlying the inter-individual differences in response to antidepressant therapy and tests which factors can predict response to treatment.

Current research projects
  • Characterization of resilience and its neurobiological basis in the mouse model
  • Development of an animal experimental model for stress inoculation
  • Characterization of the actin-interacting protein DRR1 as a factor promoting resilience
  • Identification of the molecular mechanisms of the resilience promoting properties of ketamine and other pharmacological model substances using the TRAP/INTACT approach
  • Development of instruments for dynamic system analysis in resilience research (IDSAIR)
External cooperation partners
  • Prof. Dr Amparo Acker-Palmer, Institute of Cell Biology and Neuroscience, Goethe University Frankfurt
  • Dr Dr Elisabeth Binder, Max Planck Institute for Psychiaty, Munich
  • Prof. David Lyons, PhD, Department of Psychiatry and Behavioral Sciences, Stanford University, USA
  • Prof. Helen Mayberg, MD, Departments of Psychiatry, Neurology, and Radiology, Emory University, Atlanta, USA
  • Dr. Theo Rein, Max Planck Institute for Psychiaty, Munich
  • Prof. Dr Marco Rust, Institute of Physiological Chemistry, Philipps University Marburg
  • Prof. Dr. Chris Turck, Max Planck Institute for Psychiaty, Munich
Sponsorships
  • German Research Foundation (DFG)
  • Boehringer Ingelheim Foundation
  • MWWK
Key Publications

Ayash S, Schmitt U, Müller MB (2020) Chronic social defeat-induced social avoidance as a proxy of stress resilience in mice involves conditioned learning. J Psychiatr Res 120:64-71. doi: 10.1016/j.jpsychires.2019.10.001.

>> Link to Pubmed

Jene T, Gassen NC, Opitz V, Endres K, Müller MB, van der Kooij MA (2018) Temporal profiling of an acute stress-induced behavioral phenotype in mice and role of hippocampal DRR1. Psychoneuroendocrinology 91:149-158. doi: 10.1016/j.psyneuen.2018.03.0041.

>> Link to Pubmed

Carrillo-Roa T, Labermaier C, Weber P, Herzog DP, Lareau C, Santarelli S, Wagner KV, Rex-Haffner M, Harbich D, Scharf SH, Nemeroff CB, Dunlop BW, Craighead WE, Mayberg HS, Schmidt MV, Uhr M, Holsboer F, Sillaber I, Binder EB, Müller MB (2017) Common genes associated with antidepressant response in mouse and man identify key role of glucocorticoid receptor sensitivity. PLoS Biol 15(12):e2002690. doi: 10.1371/journal.pbio.2002690.

>> Link to Pubmed

Kalisch R, Baker DG, Basten U, Boks MP, Bonanno GA, Brummelman E, Chmitorz A, Fernàndez G, Fiebach CJ, Galatzer-Levy I, Geuze E, Groppa S, Helmreich I, Hendler T, Hermans EJ, Jovanovic T, Kubiak T, Lieb K, Lutz B, Müller MB, Murray RJ, Nievergelt CM, Reif A, Roelofs K, Rutten BPF, Sander D, Schick A, Tüscher O, Diest IV, Harmelen AV, Veer IM, Vermetten E, Vinkers CH, Wager TD, Walter H, Wessa M, Wibral M, Kleim B (2017) The resilience framework as a strategy to combat stress-related disorders. Nat Hum Behav 1(11):784-790. doi: 10.1038/s41562-017-0200-8.

>> Link to Pubmed

Wagner S, Engel A, Engelmann J, Herzog D, Dreimüller N, Müller MB, Tadic A, Lieb K (2017) Early improvement as a resilience signal predicting later remission to antidepressant treatment in patients with Major Depressive Disorder: Systematic review and meta-analysis. J Psychiatr Res. doi:10.1016/j.jpsychires.2017.07.003.

>> Link to Pubmed

Kalisch R, Müller MB, Tüscher O (2015) A conceptual framework for the neurobiological study of resilience. Behav Brain Sci 38:e92. doi: 10.1017/S0140525X1400082.

>> Link to Pubmed

Masana M, Jukic MM, Kretzschmar A, Wagner KV, Westerholz S, Schmidt MV, Rein T, Brodski C, Müller MB (2015) Deciphering the spatio-temporal expression and stress regulation of Fam107B, the paralog of the resilience-promoting protein DRR1 in the mouse brain. Neuroscience 290:147-58. doi: 10.1016/j.neuroscience.2015.01.026.

>> Link to Pubmed

Masana M, Su Y-A, Jansen L, Westerholz S, Liebl C, Wagner KV, Schmidt MV, Rein T, Müller MB (2014) The stress-inducible actin-interacting protein DRR1 shapes social behavior. Psychoneuroendocrinology 48:98-110.

>> Link to Pubmed

Schmidt MV, Schülke J-P, Liebl C, Stiess M, Avrabos C, Bock J, Wochnik GM, Davies HA, Zimmermann N, Scharf SH, Trümbach D, Wurst W, Zieglgänsberger W, Turck C, Holsboer F, Stewart MG, Bradke F, Eder M, Müller MB*, Rein T* (2011) The tumor suppressor DRR1 is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition. Proc Natl Acad Sci USA 108: 17213-17218. *shares senior authors

>> Link to Pubmed
Contact
Leibniz Institute for Resilience Research (LIR)
Wallstraße 7
55122 Mainz
Phone: +49 (0)6131 89448-77
Further Information