RG Stroh
Lead:
Prof. Dr Albrecht Stroh
Research Group Leader and Head of the Mainz Animal Imaging Center LIR, Professor Institute of Pathophysiology, University Medical Center Mainz
Saleh Altahini
Wei Fan, PhD, Postdoc
Merve Ilhan
Julian Merz
Nicolas Ruffini, PhD student
Anna Wierczeiko, PhD student
The research group aims to decipher the neural basis of resilient behaviour in mouse models of resilience. The main focus is on the notion that resilience must be reflected in the initial processing of sensory afferents in the cortex. In the behaving rodent, local representation as well as cortico-cortical processing and finally the interpretation of these stimuli are investigated. Thus, direct causal conclusions can be drawn between spatio-temporal network patterns and resilient vs. susceptible behaviour. A main focus here is on slow network oscillations.
- Learning Resilience
- Investigation of the regulation of neural excitability and the functionality of cortiocortical networks in relation to resilience: a multimodal and translational approach
- Reflection of the resilient phenotype in brain-wide resting networks
- Role of spontaneous activity in a mesoprefrontal circuit in the long-term consolidation of the extinction memory
- Development of instruments for dynamic systems analysis in resilience research (IDSAIR)
- Prof. Dr Rainer Heintzmann, Leibniz Institute of Photonic Technology e.V., Jena
- Prof. Dr Cornelius Faber, Institute of Clinical Radiology, University of Münster
- Prof. Dr William Moody, Department of Biology, University of Washington, Seattle, USA
- Prof. Dr Gil Westmeyer, TUM School of Medicine, Technical University Munich
- German Research Foundation (DFG)
- Boehringer Ingelheim Foundation
- MWWK
Adelsberger H, Grienberger C, Stroh A, Konnerth A (2014) In vivo calcium recordings and channelrhodopsin-2 activation through an optical fiber. Cold Spring Harb Protoc 2014(10).
>> Link to PubmedCheng J, Sahani S, Hausrat T, Yang J-W, Ji H, Schmarowski N, Endle H, Liu X, Li Y, Böttche R, Radyushkin K, Maric H-M, Hoerder-Suabedissen A, Molnár Z, Prouvot P-H, Trimbuch T, Ninnemann O, Huai J, Fan W, Visentin B, Sabbadini R, Strømgaard K, Stroh A, Luhmann H, Kneussel M, Nitsch R, Vogt J (2016) Precise somatotopic thalamo-cortical axon guidance depends on LPA-mediated PRG-2/Radixin signaling. Neuron 92(1):126-142.
>> Link to PubmedCleppien D, Aedo-Jury F, Stroh A (2022) (2022) Beyond correlation: functional OPTO-MAgnetic Integration Concept (OPTOMAIC) to reveal the brain-wide signature of local neuronal signals-of-interest. Neurophotonics. Neurophotonics. 2022 Jul;9(3):032213. doi: 10.1117/1.NPh.9.3.032213. Epub 2022 Jul 6.
>> Link to PubmedFu T, Arnoux I, Döring J, Backhaus H, Watari H, Stasevicius I, Fan W, Stroh A (2021). Exploring 2-P optogenetics beyond 1100 nm for specific and effective all-optical physiology. iScience 24(3)102184
>> Link to PubmedIlhan-Bayrakcı M, Cabral-Calderin Y, Bergmann TO, Tüscher O, Stroh A (2022). Individual Slow Wave Events Give Rise to Macroscopic fMRI Signatures and Drive the Strength of the BOLD Signal in Human Resting-State EEG-fMRI Recordings. Cereb Cortex. 2022 Oct 20;32(21):4782-4796. doi: 10.1093/cercor/bhab516. Epub 2022 Jan 30
>> Link to PubmedJubal ER, Schwalm M, dos Santos Guilherme M, Schuck M, Reinhardt S, Tose A, Barger Z, Roesler MK, Ruffini N, Wierczeiko A, Schmeisser MJ, Schmitt U, Endres K, Stroh A (2021). Acitretin reverses early functional network degradation in a mouse model of familial Alzheimer’s disease. Sci Rep 11(1):6649.
>> Link to PubmedMeyer B, Mann C, Götz M, Gerlicher A, Saase V, Yuen KSL, Aedo-Jury F, Gonzalez-Escamilla G, Stroh A, Kalisch R (2019) Increased Neural Activity in Mesostriatal Regions after Prefrontal Transcranial Direct Current Stimulation and l-DOPA Administration. J Neurosci 39(27):5326-5335. doi: 10.1523/JNEUROSCI.3128-18.2019
>> Link to PubmedSchmid F, Wachsmuth L, Schwalm M, Prouvot P-H, Jubal E R, Fois C, Pramanik G, Zimmer C, Faber C, Stroh A (2016) Assessing sensory versus optogenetic network activation by combining (o)fMRI with optical Ca2+ recordings. Journal of Cerebral Blood Flow & Metabolism 36(11):1885-1900.
>> Link to PubmedSchwalm M, Schmid F, Wachsmuth L, Fois C, Prouvot PH, Kronfeld A, Backhaus H, Albers F, Faber C, Stroh A (2017) Cortex-wide BOLD fMRI activity reflects locally-recorded slow oscillation-associated calcium waves. eLife Sep 15;6.
>> Link to PubmedSchwalm M, Tabuena DR, Easton C, Richner TJ, Mourad P, Watari H, Moody WJ, Stroh A (2022). Functional States Shape the Spatiotemporal Representation of Local and Cortex-wide Neural Activity in Mouse Sensory Cortex. J Neurophysiol. 2022 Oct 1;128(4):763-777. doi: 10.1152/jn.00424.2021. Epub 2022 Aug 17
>> Link to PubmedStroh A, Adelsberger H, Groh A, Rühlmann C, Fischer S, Schierloh A, Deisseroth K, Konnerth A. (2013) Making waves: initiation and propagation of corticothalamic Ca2+ waves in vivo. Neuron 77: 1136-1150.
>> Link to PubmedTabuena DR, Huynh R, Metcalf J, Richner T, Stroh A, Brunton BW, Moody WJ, Easton CR (2022). Large-scale waves of activity in the neonatal mouse brain in vivo occur almost exclusively during sleep cycles. Dev Neurobiol. 2022 Oct 17. doi: 10.1002/dneu.22901. Online ahead of print
>> Link to PubmedYeganeh F, Knauer K, Guimarães Backhaus R, Yang JW, Stroh A, Luhmann HJ, Stüttgen MC (2022) Effects of optogenetic inhibition of a small fraction of parvalbumin-positive interneurons on the representation of sensory stimuli in mouse barrel cortex. Sci Rep. 2022 Nov 12;12(1):19419. doi: 10.1038/s41598-022-24156-y
>> Link to PubmedZaer H, Deshmukh A, Orlowski D, Fan W, Prouvot P-H, Nørgaard Glud A, Jensen M B, Schjødt Worm E, Lukacova S, Werenberg Mikkelsen T, Moberg Fitting L, Adler J R, Schneider M B, Snejbjerg Jensen M, Morizio J, Hedemann Sørensen J C, Stroh A (2021). An intracortical implantable brain-computer interface for telemetric real-time recording and manipulation of neuronal circuits for closed-loop intervention. Front. Hum. Neurosci. 15:618626.
>> Link to PubmedZaer H, Fan W, Orlowski D, Glud AN, Jensen MB, Worm ES, Lukacova S, Mikkelsen TW, Fitting LM, Jacobsen LM, Portmann T, Hsieh JY, Noel C, Weidlich G, Chung W, Riley P, Jenkins C, Adler JR Jr, Schneider MB, Sørensen JCH, Stroh A (2022). Non-ablative doses of focal ionizing radiation alters function of central neural circuits. Brain Stimul. 2022 Apr 5;15(3):586-597. doi: 10.1016/j.brs.2022.04.001
>> Link to PubmedZaer H, Fan W, Orlowski D, Glud AN, Andersen ASM, Schneider MB; Adler JR, Stroh A, Sørensen JCH. (2020). A perspective of international collaboration through web-based telecommunication - inspired by COVID-19 crisis. Front. Hum. Neurosci 14:577465
>> Link to Pubmed