RG Stroh
Lead:
Prof. Dr Albrecht Stroh
Research Group Leader LIR, Professor of Physiology, Director Institute of Physiology I, University Hospital Muenster (UKM)
Dr. Dirk Cleppien I Email: dirk.cleppien@lir-mainz.de
Julian Merz I Email: julian.merz@lir-mainz.de
The research group aims to decipher the neural basis of resilient behaviour in mouse models of resilience. The main focus is on the notion that resilience must be reflected in the initial processing of sensory afferents in the cortex. In the behaving rodent, local representation as well as cortico-cortical processing and finally the interpretation of these stimuli are investigated. Thus, direct causal conclusions can be drawn between spatio-temporal network patterns and resilient vs. susceptible behaviour. A main focus here is on slow network oscillations.
- Learning Resilience (https://learning-resilience.de/)
- Investigation of the regulation of neural excitability and the functionality of cortiocortical networks in relation to resilience: a multimodal and translational approach
- Reflection of the resilient phenotype in brain-wide resting networks
- Role of spontaneous activity in a mesoprefrontal circuit in the long-term consolidation of the extinction memory
- Prof. Dr. John Adler, Deptartment of Neurosurgery, Stanford University, USA
- Prof. Dr William Moody, Department of Biology, University of Washington, Seattle, USA
- Prof. Jan Marino Ramirez, Center for Integrative Brain Research, Seattle Children’s Research Institute, Seattle, USA
- German Research Foundation (DFG)
- Boehringer Ingelheim Foundation
- MWWK
Cleppien D, Aedo-Jury F, Stroh A (2022) Beyond correlation: functional OPTO-MAgnetic Integration Concept (OPTOMAIC) to reveal the brain-wide signature of local neuronal signals-of-interest. Neurophotonics. 9(3):032213. doi:10.1117/1.NPh.9.3.032213
>> Link to PubmedIlhan-Bayrakcı M, Cabral-Calderin Y, Bergmann TO, Tüscher O, Stroh A (2022) Individual slow wave events give rise to macroscopic fMRI signatures and drive the strength of the BOLD signal in human resting-state EEG-fMRI recordings. Cereb Cortex. 32(21):4782–96. doi:10.1093/cercor/bhab516
>> Link to PubmedSchwalm M, Tabuena DR, Easton C, Richner TJ, Mourad P, Watari H, Moody WJ, Stroh A (2022) Functional states shape the spatiotemporal representation of local and cortex-wide neural activity in mouse sensory cortex. J Neurophysiol. 128(4):763–77. doi:10.1152/jn.00424.2021
>> Link to PubmedTabuena DR, Huynh R, Metcalf J, Richner T, Stroh A, Brunton BW, Moody WJ, Easton CR (2022) Large-scale waves of activity in the neonatal mouse brain in vivo occur almost exclusively during sleep cycles. Dev Neurobiol. doi:10.1002/dneu.22901
>> Link to PubmedYeganeh F, Knauer K, Guimarães Backhaus R, Yang JW, Stroh A, Luhmann HJ, Stüttgen MC (2022) Effects of optogenetic inhibition of a small fraction of parvalbumin-positive interneurons on the representation of sensory stimuli in mouse barrel cortex. Sci Rep. 12(1):19419. doi:10.1038/s41598-022-24156-y
>> Link to PubmedZaer H, Fan W, Orlowski D, Glud AN, Jensen MB, Worm ES, Lukacova S, Mikkelsen TW, Fitting LM, Jacobsen LM, Portmann T, Hsieh JY, Noel C, Weidlich G, Chung W, Riley P, Jenkins C, Adler JR Jr, Schneider MB, Sørensen JCH, Stroh A (2022) Non-ablative doses of focal ionizing radiation alters function of central neural circuits. Brain Stimul. 15(3):586–97. doi:10.1016/j.brs.2022.04.001
>> Link to PubmedFu T, Arnoux I, Döring J, Backhaus H, Watari H, Stasevicius I, Fan W, Stroh A (2021) Exploring 2-P optogenetics beyond 1100 nm for specific and effective all-optical physiology. iScience. 24(3):102184. doi:10.1016/j.isci.2021.102184
>> Link to PubmedJubal ER, Schwalm M, dos Santos Guilherme M, Schuck M, Reinhardt S, Tose A, Barger Z, Roesler MK, Ruffini N, Wierczeiko A, Schmeisser MJ, Schmitt U, Endres K, Stroh A (2021) Acitretin reverses early functional network degradation in a mouse model of familial Alzheimer’s disease. Sci Rep. 11(1):6649. doi:10.1038/s41598-021-85913-z
>> Link to PubmedZaer H, Deshmukh A, Orlowski D, Fan W, Prouvot P-H, Nørgaard Glud A, Jensen MB, Schjødt Worm E, Lukacova S, Werenberg Mikkelsen T, Moberg Fitting L, Adler JR, Schneider MB, Snejbjerg Jensen M, Morizio J, Hedemann Sørensen JC, Stroh A (2021) An intracortical implantable brain-computer interface for telemetric real-time recording and manipulation of neuronal circuits for closed-loop intervention. Front Hum Neurosci. 15:618626. doi:10.3389/fnhum.2021.618626
>> Link to PubmedZaer H, Fan W, Orlowski D, Glud AN, Andersen ASM, Schneider MB, Adler JR, Stroh A, Sørensen JCH (2020) A perspective of international collaboration through web-based telecommunication - inspired by COVID-19 crisis. Front Hum Neurosci. 14:577465. doi:10.3389/fnhum.2020.577465
>> Link to PubmedMeyer B, Mann C, Götz M, Gerlicher A, Saase V, Yuen KSL, Aedo-Jury F, Gonzalez-Escamilla G, Stroh A, Kalisch R (2019) Increased neural activity in mesostriatal regions after prefrontal transcranial direct current stimulation and l-DOPA administration. J Neurosci. 39(27):5326–35. doi:10.1523/JNEUROSCI.3128-18.2019
>> Link to PubmedSchwalm M, Schmid F, Wachsmuth L, Fois C, Prouvot PH, Kronfeld A, Backhaus H, Albers F, Faber C, Stroh A (2017) Cortex-wide BOLD fMRI activity reflects locally-recorded slow oscillation-associated calcium waves. eLife. 6:e27602. doi:10.7554/eLife.27602
>> Link to PubmedCheng J, Sahani S, Hausrat T, Yang JW, Ji H, Schmarowski N, Endle H, Liu X, Li Y, Böttche R, Radyushkin K, Maric HM, Hoerder-Suabedissen A, Molnár Z, Prouvot PH, Trimbuch T, Ninnemann O, Huai J, Fan W, Visentin B, Sabbadini R, Strømgaard K, Stroh A, Luhmann H, Kneussel M, Nitsch R, Vogt J (2016) Precise somatotopic thalamo-cortical axon guidance depends on LPA-mediated PRG-2/Radixin signaling. Neuron. 92(1):126–42. doi:10.1016/j.neuron.2016.08.008
>> Link to PubmedSchmid F, Wachsmuth L, Schwalm M, Prouvot PH, Jubal ER, Fois C, Pramanik G, Zimmer C, Faber C, Stroh A (2016) Assessing sensory versus optogenetic network activation by combining (o)fMRI with optical Ca2+ recordings. J Cereb Blood Flow Metab. 36(11):1885–1900. doi:10.1177/0271678X16652737
>> Link to PubmedAdelsberger H, Grienberger C, Stroh A, Konnerth A (2014) In vivo calcium recordings and channelrhodopsin-2 activation through an optical fiber. Cold Spring Harb Protoc. 2014(10):pdb.prot084145. doi:10.1101/pdb.prot084145
>> Link to PubmedStroh A, Adelsberger H, Groh A, Rühlmann C, Fischer S, Schierloh A, Deisseroth K, Konnerth A (2013) Making waves: initiation and propagation of corticothalamic Ca2+ waves in vivo. Neuron. 77(6):1136–50. doi:10.1016/j.neuron.2013.01.031
>> Link to Pubmed