RG Stroh

Lead:
Prof. Dr Albrecht Stroh

Research Group Leader and Head of the Mainz Animal Imaging Center LIR, Professor Institute of Pathophysiology, University Medical Center Mainz

Staff

Dr. Felipe Aedo-Jury, Postdoc

Hendrik Backhaus, PhD student

Anna Wierczeiko, PhD student

Nicolas Ruffini, PhD student

Nuse Afahaene, Technician

Saleh Altahini

Research group description

The research group aims to decipher the neural basis of resilient behaviour in mouse models of resilience. The main focus is on the notion that resilience must be reflected in the initial processing of sensory afferents in the cortex. In the behaving rodent, local representation as well as cortico-cortical processing and finally the interpretation of these stimuli are investigated. Thus, direct causal conclusions can be drawn between spatio-temporal network patterns and resilient vs. susceptible behaviour. A main focus here is on slow network oscillations.

Current research projects

Investigation of the regulation of neural excitability and the functionality of cortiocortical networks in relation to resilience: a multimodal and translational approach
Reflection of the resilient phenotype in brain-wide resting networks
Role of spontaneous activity in a mesoprefrontal circuit in the long-term consolidation of the extinction memory
Development of instruments for dynamic systems analysis in resilience research (IDSAIR)

External cooperation partners

Prof. Dr Rainer Heintzmann, Leibniz Institute of Photonic Technology e.V., Jena
Prof. Dr Cornelius Faber, Institute of Clinical Radiology, University of Münster
Prof. Dr William Moody, Department of Biology, University of Washington, Seattle, USA
Prof. Dr Gil Westmeyer, TUM School of Medicine, Technical University Munich

Sponsorships

German Research Foundation (DFG)
Boehringer Ingelheim Foundation
MWWK

Key Publications

Meyer B, Mann C, Götz M, Gerlicher A, Saase V, Yuen KSL, Aedo-Jury F, Gonzalez-Escamilla G, Stroh A, Kalisch R (2019) Increased Neural Activity in Mesostriatal Regions after Prefrontal Transcranial Direct Current Stimulation and l-DOPA Administration. J Neurosci 39(27):5326-5335. doi: 10.1523/JNEUROSCI.3128-18.2019

>> Link to Pubmed

Schwalm M, Schmid F, Wachsmuth L, Fois C, Prouvot PH, Kronfeld A, Backhaus H, Albers F, Faber C, Stroh A (2017) Cortex-wide BOLD fMRI activity reflects locally-recorded slow oscillation-associated calcium waves. eLife Sep 15;6.

>> Link to Pubmed

Cheng J, Sahani S, Hausrat T, Yang J-W, Ji H, Schmarowski N, Endle H, Liu X, Li Y, Böttche R, Radyushkin K, Maric H-M, Hoerder-Suabedissen A, Molnár Z, Prouvot P-H, Trimbuch T, Ninnemann O, Huai J, Fan W, Visentin B, Sabbadini R, Strømgaard K, Stroh A, Luhmann H, Kneussel M, Nitsch R, Vogt J (2016) Precise somatotopic thalamo-cortical axon guidance depends on LPA-mediated PRG-2/Radixin signaling. Neuron 92(1):126-142.

>> Link to Pubmed

Schmid F, Wachsmuth L, Schwalm M, Prouvot P-H, Jubal E R, Fois C, Pramanik G, Zimmer C, Faber C, Stroh A (2016) Assessing sensory versus optogenetic network activation by combining (o)fMRI with optical Ca2+ recordings. Journal of Cerebral Blood Flow & Metabolism 36(11):1885-1900.

>> Link to Pubmed

Adelsberger H, Grienberger C, Stroh A, Konnerth A (2014) In vivo calcium recordings and channelrhodopsin-2 activation through an optical fiber. Cold Spring Harb Protoc 2014(10).

>> Link to Pubmed

Stroh A, Adelsberger H, Groh A, Rühlmann C, Fischer S, Schierloh A, Deisseroth K, Konnerth A. (2013) Making waves: initiation and propagation of corticothalamic Ca2+ waves in vivo. Neuron 77: 1136-1150.

>> Link to Pubmed