RG Stroh
Lead:
RG Stroh
Research Group Leader and Head of the Mainz Animal Imaging Center LIR, Professor Institute of Pathophysiology, University Medical Center Mainz
Dr Felipe Aedo-Jury, Postdoc
Wei Fan, PhD, Postdoc
Ting Fu, PhD, Postdoc
Nicolas Ruffini, PhD student
Anna Wierczeiko, PhD student
The research group aims to decipher the neural basis of resilient behaviour in mouse models of resilience. The main focus is on the notion that resilience must be reflected in the initial processing of sensory afferents in the cortex. In the behaving rodent, local representation as well as cortico-cortical processing and finally the interpretation of these stimuli are investigated. Thus, direct causal conclusions can be drawn between spatio-temporal network patterns and resilient vs. susceptible behaviour. A main focus here is on slow network oscillations.
- Investigation of the regulation of neural excitability and the functionality of cortiocortical networks in relation to resilience: a multimodal and translational approach
- Reflection of the resilient phenotype in brain-wide resting networks
- Role of spontaneous activity in a mesoprefrontal circuit in the long-term consolidation of the extinction memory
- Development of instruments for dynamic systems analysis in resilience research (IDSAIR)
- Prof. Dr Rainer Heintzmann, Leibniz Institute of Photonic Technology e.V., Jena
- Prof. Dr Cornelius Faber, Institute of Clinical Radiology, University of Münster
- Prof. Dr William Moody, Department of Biology, University of Washington, Seattle, USA
- Prof. Dr Gil Westmeyer, TUM School of Medicine, Technical University Munich
- German Research Foundation (DFG)
- Boehringer Ingelheim Foundation
- MWWK
Meyer B, Mann C, Götz M, Gerlicher A, Saase V, Yuen KSL, Aedo-Jury F, Gonzalez-Escamilla G, Stroh A, Kalisch R (2019) Increased Neural Activity in Mesostriatal Regions after Prefrontal Transcranial Direct Current Stimulation and l-DOPA Administration. J Neurosci 39(27):5326-5335. doi: 10.1523/JNEUROSCI.3128-18.2019
>> Link to PubmedSchwalm M, Schmid F, Wachsmuth L, Fois C, Prouvot PH, Kronfeld A, Backhaus H, Albers F, Faber C, Stroh A (2017) Cortex-wide BOLD fMRI activity reflects locally-recorded slow oscillation-associated calcium waves. eLife Sep 15;6.
>> Link to PubmedCheng J, Sahani S, Hausrat T, Yang J-W, Ji H, Schmarowski N, Endle H, Liu X, Li Y, Böttche R, Radyushkin K, Maric H-M, Hoerder-Suabedissen A, Molnár Z, Prouvot P-H, Trimbuch T, Ninnemann O, Huai J, Fan W, Visentin B, Sabbadini R, Strømgaard K, Stroh A, Luhmann H, Kneussel M, Nitsch R, Vogt J (2016) Precise somatotopic thalamo-cortical axon guidance depends on LPA-mediated PRG-2/Radixin signaling. Neuron 92(1):126-142.
>> Link to PubmedSchmid F, Wachsmuth L, Schwalm M, Prouvot P-H, Jubal E R, Fois C, Pramanik G, Zimmer C, Faber C, Stroh A (2016) Assessing sensory versus optogenetic network activation by combining (o)fMRI with optical Ca2+ recordings. Journal of Cerebral Blood Flow & Metabolism 36(11):1885-1900.
>> Link to PubmedAdelsberger H, Grienberger C, Stroh A, Konnerth A (2014) In vivo calcium recordings and channelrhodopsin-2 activation through an optical fiber. Cold Spring Harb Protoc 2014(10).
>> Link to PubmedStroh A, Adelsberger H, Groh A, Rühlmann C, Fischer S, Schierloh A, Deisseroth K, Konnerth A. (2013) Making waves: initiation and propagation of corticothalamic Ca2+ waves in vivo. Neuron 77: 1136-1150.
>> Link to Pubmed