RG Tüscher

Lead:
Prof. Dr Oliver Tüscher

Research Group Leader and Head of Clinical Investigation Center LIR, Professor for Clinical Resilience Research University Medical Center of the Johannes Gutenberg-University Mainz

Staff

Merve Ilhan, PhD student

Dr Bianca Kollmann, Postdoc

Karolina Kurth, PhD student

Lara Mey, PhD student

Thies Moolenaar, PhD student

Edoardo Pinzuti, PhD student

Michael Schaum, PhD student

Research group description

Our research group uses modern methods of cognitive behavioural research (behavioural tests and ambulatory assessments) and neurophysiology (fMRI, DTI/VBM, EEG/fMRI, EEG, MEG, EEG/MEG, PET, and imaging genetics) to understand neurocognitive mechanisms of mental resilience of stress-related diseases. Thematic focuses are the systematic study of self-control as a resilience mechanism, in particular the cognitive domains of emotion regulation (ER), impulse control (IC), attention (AC), and social interaction, as well as the translational mechanisms of stress vaccination, taking into account interindividual differences and age processes. Neuronally, hypotheses on oscillatory mechanisms and differences in network excitability on individual resilience are investigated.

Current research projects

Translational mechanisms of stress vaccination as resilience mechanism
Mechanisms of emotional interference control
Mechanisms of proactive interference control - Method development
Neuronal mechanisms of the brain-wide resting networks in humans
Development of instruments for dynamic systems analysis in resilience research (IDSAIR)

External cooperation partners

Prof. Dr Michael Wibral, Campus Institute for Dynamics of Biological Networks, Georg August University Göttingen
Prof. Dr Dr. Henrik Walter, Psychiatrie, Humboldt University, Charité, Berlin
Prof. Dr Birte Forstmann, University of Amsterdam, the Netherlands
Prof. Dr David Silbersweig, Brigham & Woman's Hospital, Harvard University, Boston, USA

Sponsorships

German Research Foundation (DFG)
Boehringer Ingelheim Foundation
MWWK

Key Publications

Ahrens KF, Neumann RJ, Kollmann B, Plichta MM, Lieb K*, Tüscher O*, Reif A* (in press). Differential impact of COVID-related lockdown on mental health in Germany, Letter to the editor (peer-reviewed, original data). World Psychiat. (*shared last authors)

Kampa M, Schick A, Sebastian A, Wessa M, Tüscher O, Kalisch R, Yuen K (2020) Replication of fMRI group activations in the neuroimaging battery for the Mainz Resilience Project (MARP). Neuroimage 204:116223. doi: 10.1016/j.neuroimage.2019.116223

>> Link to Pubmed

Sebastian A, Schick A, Sandner M, Werzlau RM, Chmitorz A, Lieb K, Tüscher O (2020). Perceived threat modulates inhibitory performance. Emotion. doi: 10.1037/emo0000746

>> Link to Pubmed

Wolf D, Tüscher O, Teipel S, Mierau A, Strüder H, Drzezga A, Baier B, Binder H, Fellgiebel A; German AgeGain study group (2018) Mechanisms and modulators of cognitive training gain transfer in cognitively healthy aging: study protocol of the AgeGain study. Trials 19(1):337. doi: 10.1186/s13063-018-2688-2.23

>> Link to Pubmed

Chmitorz A, Wenzel M, Stieglitz RD, Kunzler A, Bagusat C, Helmreich I, Gerlicher A, Kampa M, Kubiak T, Kalisch R, Lieb K, Tüscher O (2018) Population-based validation of a German version of the Brief Resilience Scale. PLoS One 13(2):e0192761. doi: 10.1371/journal.pone.0192761

>> Link to Pubmed

Kalisch R, Baker DG, Basten U, Boks MP, Bonanno GA, Brummelman E, Chmitorz A, Fernàndez G, Fiebach CJ, Galatzer-Levy I, Geuze E, Groppa S, Helmreich I, Hendler T, Hermans EJ, Jovanovic T, Kubiak T, Lieb K, Lutz B, Müller MB, Murray RJ, Nievergelt CM, Reif A, Roelofs K, Rutten BPF, Sander D, Schick A, Tüscher O, Diest IV, Harmelen AV, Veer IM, Vermetten E, Vinkers CH, Wager TD, Walter H, Wessa M, Wibral M, Kleim B (2017) The resilience framework as a strategy to combat stress-related disorders. Nat Hum Behav 1(11):784-790. doi: 10.1038/s41562-017-0200-8

>> Link to Pubmed

Franke AG, Gränsmark P, Agricola A, Schühle K, Rommel T, Sebastian A, Balló HE, Gorbulev S, Gerdes C, Frank B, Ruckes C, Tüscher O, Lieb K (2017) Methylphenidate, modafinil, and caffeine for cognitive enhancement in chess: A double-blind, randomised controlled trial. Eur Neuropsychopharmacol 27(3):248-260.

>> Link to Pubmed

Sebastian A, Rössler K, Wibral M, Mobascher A, Lieb K, Jung P, Tüscher O (2017). Neural architecture of selective stopping strategies: Distinct brain activity patterns are associated with attentional capture but not with outright stopping. J Neurosci 37(40):9785-9794. doi: 10.1523/JNEUROSCI.1476-17.2017

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Schmüser L, Sebastian A, Mobascher A, Lieb K, Feige B, Tüscher O (2016) Data-driven analysis of simultaneous EEG/fMRI reveals neurophysiological phenotypes of impulse control. Hum Brain Mapp 37(9):3114-36.

>> Link to Pubmed

Sebastian A, Jung P, Neuhoff J, Wibral M, Fox PT, Lieb K, Fries P, Eickhoff SB, Tüscher O, Mobascher A (2016) Dissociable attentional and inhibitory networks of dorsal and ventral areas of the right inferior frontal cortex: a combined task-specific and coordinate-based meta-analytic fMRI study. Brain Struct Funct 221(3):1635-51.

>> Link to Pubmed

Kalisch R, Müller MB, Tüscher O (2015) Advancing empirical resilience research. Behav Brain Sci 38:e128. doi: 10.1017/S0140525X15000023

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Kalisch R, Müller MB, Tüscher O (2015) A conceptual framework for the neurobiological study of resilience Behav Brain Sci 38:e92. doi: 10.1017/S0140525X1400082X

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Endres K, Fahrenholz F, Lotz J, Hiemke C, Teipel S, Lieb K, Tüscher O*, Fellgiebel A* (2014). Increased CSF APPs-α levels in patients with Alzheimer disease treated with acitretin. Neurology 83(21):1930-1935. doi: 10.1212/WNL.0000000000001017 (*equal contribution)

>> Link to Pubmed