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RG Tüscher

Prof. Dr Oliver Tüscher

Professor for Mental Health and Resilience in the Old Age University Medical Center of the Johannes Gutenberg-University Mainz


Merve Ilhan, PhD student

Dr Bianca Kollmann, Postdoc

Edoardo Pinzuti, PhD student

Nicolas Ruffini, PhD student

Dr Alexandra Sebastian, Postdoc

Lisa von Boros, PhD student

Federico Zappalà, PhD student

Research group description

Our research group uses modern methods of cognitive behavioural research (behavioural tests and ambulatory assessments) and neurophysiology (fMRI, DTI/VBM, EEG/fMRI, EEG, MEG, EEG/MEG, PET, and imaging genetics) to understand neurocognitive mechanisms of mental resilience of stress-related diseases. Thematic focuses are the systematic study of self-control as a resilience mechanism, in particular the cognitive domains of emotion regulation (ER), impulse control (IC), attention (AC), and social interaction, as well as the translational mechanisms of stress vaccination, taking into account interindividual differences and age processes. Neuronally, hypotheses on oscillatory mechanisms and differences in network excitability on individual resilience are investigated.

Current research projects
  • Translational mechanisms of stress vaccination as resilience mechanism
  • Mechanisms of emotional interference control
  • Mechanisms of proactive interference control - Method development
  • Neuronal mechanisms of the brain-wide resting networks in humans
  • Development of instruments for dynamic systems analysis in resilience research (IDSAIR)
External cooperation partners
  • Prof. Dr Michael Wibral, Campus Institute for Dynamics of Biological Networks, Georg August University Göttingen
  • Prof. Dr Dr. Henrik Walter, Psychiatrie, Humboldt University, Charité, Berlin
  • Prof. Dr Birte Forstmann, University of Amsterdam, the Netherlands
  • Prof. Dr David Silbersweig, Brigham & Woman's Hospital, Harvard University, Boston, USA
  • German Research Foundation (DFG)
  • Boehringer Ingelheim Foundation
  • MWWK
Key Publications

Ahrens KF, Neumann RJ, Kollmann B, Plichta MM, Lieb K*, Tüscher O*, Reif A* (in press). Differential impact of COVID-related lockdown on mental health in Germany, Letter to the editor (peer-reviewed, original data). World Psychiat. (*shared last authors)

Chmitorz A, Wenzel M, Stieglitz RD, Kunzler A, Bagusat C, Helmreich I, Gerlicher A, Kampa M, Kubiak T, Kalisch R, Lieb K, Tüscher O (2018) Population-based validation of a German version of the Brief Resilience Scale. PLoS One 13(2):e0192761. doi: 10.1371/journal.pone.0192761

>> Link to Pubmed

Endres K, Fahrenholz F, Lotz J, Hiemke C, Teipel S, Lieb K, Tüscher O*, Fellgiebel A* (2014). Increased CSF APPs-α levels in patients with Alzheimer disease treated with acitretin. Neurology 83(21):1930-1935. doi: 10.1212/WNL.0000000000001017 (*equal contribution)

>> Link to Pubmed

Franke AG, Gränsmark P, Agricola A, Schühle K, Rommel T, Sebastian A, Balló HE, Gorbulev S, Gerdes C, Frank B, Ruckes C, Tüscher O, Lieb K (2017) Methylphenidate, modafinil, and caffeine for cognitive enhancement in chess: A double-blind, randomised controlled trial. Eur Neuropsychopharmacol 27(3):248-260.

>> Link to Pubmed

Kalisch R, Baker DG, Basten U, Boks MP, Bonanno GA, Brummelman E, Chmitorz A, Fernàndez G, Fiebach CJ, Galatzer-Levy I, Geuze E, Groppa S, Helmreich I, Hendler T, Hermans EJ, Jovanovic T, Kubiak T, Lieb K, Lutz B, Müller MB, Murray RJ, Nievergelt CM, Reif A, Roelofs K, Rutten BPF, Sander D, Schick A, Tüscher O, Diest IV, Harmelen AV, Veer IM, Vermetten E, Vinkers CH, Wager TD, Walter H, Wessa M, Wibral M, Kleim B (2017) The resilience framework as a strategy to combat stress-related disorders. Nat Hum Behav 1(11):784-790. doi: 10.1038/s41562-017-0200-8

>> Link to Pubmed

Kalisch R, Müller MB, Tüscher O (2015) A conceptual framework for the neurobiological study of resilience Behav Brain Sci 38:e92. doi: 10.1017/S0140525X1400082X

>> Link to Pubmed

Kalisch R, Müller MB, Tüscher O (2015) Advancing empirical resilience research. Behav Brain Sci 38:e128. doi: 10.1017/S0140525X15000023

>> Link to Pubmed

Kampa M, Schick A, Sebastian A, Wessa M, Tüscher O, Kalisch R, Yuen K (2020) Replication of fMRI group activations in the neuroimaging battery for the Mainz Resilience Project (MARP). Neuroimage 204:116223. doi: 10.1016/j.neuroimage.2019.116223

>> Link to Pubmed

Sebastian A, Rössler K, Wibral M, Mobascher A, Lieb K, Jung P, Tüscher O (2017). Neural architecture of selective stopping strategies: Distinct brain activity patterns are associated with attentional capture but not with outright stopping. J Neurosci 37(40):9785-9794. doi: 10.1523/JNEUROSCI.1476-17.2017

>> Link to Pubmed

Sebastian A, Schick A, Sandner M, Werzlau RM, Chmitorz A, Lieb K, Tüscher O (2020). Perceived threat modulates inhibitory performance. Emotion. doi: 10.1037/emo0000746

>> Link to Pubmed

Sebastian A, Jung P, Neuhoff J, Wibral M, Fox PT, Lieb K, Fries P, Eickhoff SB, Tüscher O, Mobascher A (2016) Dissociable attentional and inhibitory networks of dorsal and ventral areas of the right inferior frontal cortex: a combined task-specific and coordinate-based meta-analytic fMRI study. Brain Struct Funct 221(3):1635-51.

>> Link to Pubmed

Schmüser L, Sebastian A, Mobascher A, Lieb K, Feige B, Tüscher O (2016) Data-driven analysis of simultaneous EEG/fMRI reveals neurophysiological phenotypes of impulse control. Hum Brain Mapp 37(9):3114-36.

>> Link to Pubmed

Wolf D, Tüscher O, Teipel S, Mierau A, Strüder H, Drzezga A, Baier B, Binder H, Fellgiebel A; German AgeGain study group (2018) Mechanisms and modulators of cognitive training gain transfer in cognitively healthy aging: study protocol of the AgeGain study. Trials 19(1):337. doi: 10.1186/s13063-018-2688-2.23

>> Link to Pubmed
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