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Prof. Dr Susann Schweiger

Research Group Leader LIR, Director of Institute for Human Genetics University Medical Center of the Johannes Gutenberg-University Mainz, Professor for Human Genetics

Contact

Leibniz-Institut für Resilienzforschung gGmbH
Wallstraße 7
55122 Mainz

+49 (0)6131 89448-00
General Information
Year of Birth

1970

Current Position

Research Group Leader, Leibniz Institute for Resilience Research (LIR), Mainz, Germany Professor for Human Genetics, Director of Institute for Human Genetics, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany

University training and degrees
11/2006

Board certification Human Genetics, Ärztekammer Berlin, Germany

1999 – 2004

Residency training Human Genetics, Charité University Medicine Berlin, Germany

08/2005 – 02/2006

Registrar: Department of Dermatology, Charité University Medicine Berlin, Germany, Full registration, Ärztekammer Hamburg, Germany

07/1994 – 06/1995

Registrar: Department of Pharmacology, University Hospital FU Berlin, Germany

10/1993 – 06/1994

Registrar: Department of Internal Medicine, University Hospital Hamburg, Germany

10/1993

Provisional registration, Ärztekammer Hamburg, Germany

10/1993

Dr. med. (M.D.); Innsbruck Medical School, Austria 10/1993; Graduation; Innsbruck Medical School, Austria

10/1987 – 10/1993

Undergraduate Training; Innsbruck Medical School, Austria

Advanced academic qualifications
10/1993

Dr. med. (M.D.); Innsbruck Medical School, Austria 10/1993; Graduation; Innsbruck Medical School, Austria

Postgraduate professional career
Since 01/2020

Research Group Leader at the Leibniz Institute for Resilience Research (LIR), Mainz, Germany

Since 01/2018

Research Group Leader at the German Resilience Center (DRZ) Mainz, Germany

Since 09/2012

Professor for Human Genetics, University Medical Center of the Johannes Gutenberg University Mainz, Germany

Director Institute for Human Genetics, University Medical Center of the Johannes Gutenberg University Mainz, Germany

08/2007 – 08/2012

Professor for Molecular Medicine, Ninewells Hospital, Dundee, Scotland, United Kingdom

Academic Lead of the Department for Human Genetics

05/2010 – 08/2012

Deputy Head of the Wellcome Trust Centre for Molecular Medicine

08/2008 – 05/2010

Head of the Centre for Oncology and Molecular Medicine

04/2005 – 08/2007

Lichtenberg Professor for Clinical and Molecular Genetics, Charité University Medicine, Berlin, Germany

1990 – 1992

M.D.-Ph.D. thesis: Institute of Organic Chemistry and Biochemistry, Freiburg, Germany; “Purification, characterization and crystallization of the membrane protein Maltoporin, the membrane-associated proteins Adrenodoxin Reduktase, and the tissue-plasminogene activator tPA” (supervisor: Georg E. Schulz, University of Freiburg, Germany)

Other professional activities or honors
2005 – 2010

Lichtenberg professorship of the “Volkswagenstiftung”

1995 – 1997

Research grant of the Max Planck Society

1987 – 1993

Member of the “Studienstiftung des Deutschen Volkes”

 

Selected Publications

Weiß M, Selig M, Friedrich J, Wierczeiko A, Diederich S, Sigel H, Bredow J, Eichler FS, Nagy A, Seyler D, Holthöfer L, Gerber S, Schweiger S, Linke M, Bley A (2025) Deep intronic SVA_E retrotransposition as a novel factor in Canavan disease pathogenesis. Hum Gene Ther. doi:10.1089/hum.2025.006. Online ahead of print.

>> Link to article

Butto T, Chongtham MC, Mungikar K, Hartwich D, Linke M, Ruffini N, Radyushkin K, Schweiger S, Winter J, Gerber S (2024) Characterization of transcriptional profiles associated with stress-induced neuronal activation in Arc-GFP mice. Mol Psychiatry. 29(19):3010-3023. doi: 10.1038/s41380-024-02555-z. PMID: 38649752

>> Link to Pubmed

Frank S, Gabessi E, Käseberg S, Bertin M, Zografidou L, Pfeiffer D, Brennenstuhl H, Falk S, Karow M, Schweiger S (2024) Absence of the RING domain in MID1 results in patterning defects in the developing human brain. LSA. doi: 10.26508/lsa.202302288

>> Link to Pubmed

Hewel C, Schmidt H, Runkel S, Kohnen W, Schweiger S, Michel A, Bikar SE, Plachter B, Hankeln T, Linke M, Gerber S (2024) Nanopore adaptive sampling of a metagenomic sample derived from a human monkeypox case. J Med Virol. doi: 10.1002/jmv.29610

>> Link to Pubmed

Krummeich J, Nardi L, Caliendo C, Aschauer D, Engelhardt V, Arlt A, Maier J, Blicker F, Kwiatkowski MD, Rolski K, Vincze K, Schneider R, Rumpel S, Gerber S, Schmeisser MJ, Schweiger S (2024) Premature cognitive decline in a mouse model of tuberous sclerosis. Aging Cell. 23(12):e14318. doi:10.1111/acel.14318

>> Link to Pubmed

Stroh A, Schweiger S, Ramirez JM, Tüscher O (2024) The selfish network: how the brain preserves behavioral function through shifts in neuronal network state. Trends Neurosci. 47(4):246-258. doi:10.1016/j.tins.2024.02.005

>> Link to Pubmed

Käseberg S, Bertin M, Menon R, Gabassi E, Todorov H, Frank S, Brennenstuhl H, Lohrer B, Winter J, Krummeich J, Winkler J, Winner B, Weis E, Hartwich D, Diederich S, Luck K, Gerber S, Lunt P, Berninger B, Falk S, Schweiger S, Karow M (2023) Dynamic X-chromosomal reactivation enhances female brain resilience. biorXiv. 2023. doi: 10.1101/2023.06.17.545424

>> Link to article

Rücklé C, Körtel N, Basilicata MF, Busch A, Zhou Y, Hoch-Kraft P, Tretow K, Kielisch F, Bertin M, Pradhan M, Musheev M, Schweiger S, Niehrs C, Rausch O, Zarnack K, Keller Valsecchi CI, König J (2023) RNA stability controlled by m6A methylation contributes to X-to-autosome dosage compensation in mammals. Nat Struct Mol Biol. 30(8):1207-1215. doi: 10.1038/s41594-023-00997-7

>> Link to Pubmed

Vennin C, Hewel C, Todorov H, Wendelmuth M, Radyushkin K, Heimbach A, Horenko I, Ayash S, Müller MB, Schweiger S, Gerber S, Lutz B (2022) A resilience-related glial-neurovascular network is transcriptionally activated after chronic social defeat in male mice. Cells. 11(21):3405. doi: 10.3390/cells11213405

>> Link to Pubmed

Cooper A, Butto T, Hammer N, Jagannath S, Fend-Guella DL, Akhtar J, Radyushkin K, Lesage F, Winter J, Strand S, Roeper J, Zechner U, Schweiger S (2020) Inhibition of histone deacetylation rescues phenotype in a mouse model of Birk-Barel Intellectual Disability syndrome. Nat Commun. 11(1):480. doi: 10.1038/s41467-019-13918-4

>> Link to article

Wendelmuth M, Willam M, Todorov H, Radyushkin K, Gerber S, Schweiger S (2020) Dynamic longitudinal behavior in animals exposed to chronic social defeat. PLoS One. 15(7):e0235268. doi: 10.1371/journal.pone.0235268

>> Link to Pubmed
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