Prof. Dr Beat Lutz
Scientific Managing Director LIR, Professor and Director of Institute of Physiological Chemistry University Medical Center of the Johannes Gutenberg-University Mainz
Leibniz-Institut für Resilienzforschung gGmbH
Wallstraße 7
55122 Mainz
Office (8:30 am to 3:00 pm)
E-mail:
verena.huber@lir-mainz.de
Phone:
+49 (0)6131-89448-77
Behavioral Genetics in mouse. Mechanisms underlying learning and memory, and stress coping. Epigenetic mechanisms underlying behavior. Lipid signaling systems (mainly on endocannabinoids and cannabinoid receptors). Roles of the endocannabinoid system in anxiety, fear memory, stress coping, synaptic plasticity, adult neurogenesis, neural development, and energy metabolism.
1961
Scientific Managing Director and Research Group Leader Leibniz Institute for Resilience Research (LIR), Mainz, Germany
Professor and Director Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg-University Mainz
Habilitation in Zoology at the LMU Munich, Germany (Prof. G. Neuweiler)
Diploma for Gymnasium teacher in chemistry, Swiss Federal Institute of Technology (ETH)
Dr. sc. nat: Swiss Federal Institute of Technology (ETH) Zurich at Institute for Cell Biology, Switzerland (supervisor: Prof. Dr. Markus Lezzi)
Doctorate work at the Institute for Cell Biology, ETH Zurich, Switzerland (Prof. M. Lezzi, Prof. H. Eppenberger)
Diploma in Natural Sciences at ETH Zurich, Switzerland
Studies in Biochemistry at ETH Zurich, Switzerland
Dr. sc. nat.: Swiss Federal Institute of Technology (ETH) Zurich at Institute for Cell Biology, Switzerland (supervisor: Prof. Dr. Markus Lezzi)
Scientific Managing Director and Research Group Leader, Leibniz Institute for Resilience Research (LIR), Mainz, Germany
Scientific Managing Director and Research Group Leader, Institute for Resilience Research, Mainz, Germany
Director of the Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
W3 Professor for Physiological Chemistry, Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University, Mainz, Germany
Independent Group Leader of the Max Planck Society at the Max Planck Institute of Psychiatry, Munich, Germany
Scientist at the DKFZ, Heidelberg, Germany (Prof. G. Schütz)
Postdoctoral positions at ETH (Zurich, Switzerland; Prof. M. Lezzi), Harvard Medical School, Boston, MA USA (Prof. G. Eichele), and Baylor College of Medicine, Houston, TX, USA (Prof. G. Eichele)
Spokesperson of the CRC1193 „Neurobiology of Resilience“
Tenure Commission at UM Mainz, Germany
Co-organizer of the International Symposium on Resilience Research
Member of Fachbereichsrat at UM Mainz, Germany
Chair of the Gordon Research Conference “Cannabinoid Functions in the CNS”
Chairperson of DFG Research Unit FOR926 (with A. Zimmer, Bonn, Germany)
Stipend from the Hertie-Foundation (Excellence Program in Neurosciences)
Organon Prize for Psychiatry
Fellowships from the Swiss National Foundation
Martin-Garcia E, Domingo-Rodriguez L, Lutz B, Maldonado R, Ruiz de Azua I (2025) Cannabinoid type-1 receptors in CaMKII neurons drive impulsivity in pathological eating behavior. Mol Metab. 92:102096. doi:10.1016/j.molmet.2025.102096
>> Link to PubmedPastore S, Hillenbrand P, Molnar N, Kovlyagina I, Chongtham MC, Sys S, Lutz B, Tevosian M, Gerber S (2025) ClearFinder: a Python GUI for annotating cells in cleared mouse brain. BMC Bioinformatics. 26(1):24. doi:10.1186/s12859-025-06039-x
>> Link to PubmedKovlyagina I, Wierczeiko A, Todorov H, Jacobi E, Tevosian M, von Engelhardt J, Gerber S, Lutz B. Leveraging interindividual variability in threat conditioning of inbred mice to model trait anxiety (2024) PLoS Biol. 22(5):e3002642. doi:10.1371/journal.pbio.3002642
>> Link to PubmedMonory K, Ruiz de Azua I, Lutz B (2024) Genetic tools in rodents to study cannabinoid functions. Curr Top Behav Neurosci. doi:10.1007/7854_2024_550
>> Link to PubmedTevosian M, Todorov H, Lomazzo E, Bindila L, Ueda N, Bassetti D, Warm D, Kirischuk S, Luhmann HJ, Gerber S, Lutz B (2023) NAPE-PLD deletion in stress-TRAPed neurons results in an anxiogenic phenotype. Transl Psychiatry. 13(1):152. doi:10.1038/s41398-023-02448-9
>> Link to PubmedBusch AM, Kovlyagina I, Lutz B, Todorov H, Gerber S (2022) beeRapp: an R shiny app for automated high-throughput explorative analysis of multivariate behavioral data. Bioinform Adv. 2(1):vbac082. doi:10.1093/bioadv/vbac082
>> Link to PubmedLeschik J, Gentile A, Cicek C, Péron S, Tevosian M, Beer A, Radyushkin K, Bludau A, Ebner K, Neumann I, Singewald N, Berninger B, Lessmann V, Lutz B (2022) Brain-derived neurotrophic factor expression in serotonergic neurons improves stress resilience and promotes adult hippocampal neurogenesis. Prog Neurobiol. 217:102333. doi:10.1016/j.pneurobio.2022.102333
>> Link to PubmedPascual Cuadrado D, Todorov H, Lerner R, Islami L, Bindila L, Gerber S, Lutz B (2022) Long-term molecular differences between resilient and susceptible mice after a single traumatic exposure. Br J Pharmacol. 179(17):4161–4180. doi:10.1111/bph.15697
>> Link to PubmedVennin C, Hewel C, Todorov H, Wendelmuth M, Radyushkin K, Heimbach A, Horenko I, Ayash S, Müller MB, Schweiger S, Gerber S, Lutz B (2022) A resilience related glial-neurovascular network is transcriptionally activated after chronic social defeat in male mice. Cells. 11(21):3405. doi:10.3390/cells11213405
>> Link to PubmedLeschik J, Lutz B, Gentile A (2021) Stress-related dysfunction of adult hippocampal neurogenesis—an attempt for understanding resilience? Int J Mol Sci. 22(14):7339. doi:10.3390/ijms22147339
>> Link to PubmedNavandar M, Martín-García E, Maldonado R, Lutz B, Gerber S, Ruiz de Azua I (2021) Transcriptional signatures in prefrontal cortex confer vulnerability versus resilience to food and cocaine addiction-like behavior. Sci Rep. 11(1):9076. doi:10.1038/s41598-021-88363-9
>> Link to PubmedDomingo-Rodriguez L, Ruiz de Azua I, Dominguez E, Senabre E, Serra I, Kummer S, Navandar M, Baddenhausen S, Hofmann C, Andero R, Gerber S, Navarrete M, Dierssen M, Lutz B, Martín-García E, Maldonado R (2020) A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction. Nat Commun. 11(1):782. doi:10.1038/s41467-020-14458-y
>> Link to PubmedLutz B (2020) Neurobiology of cannabinoid receptor signaling. Dialogues Clin Neurosci. 22(3):207–22. doi:10.31887/DCNS.2020.22.3/blutz
>> Link to Pubmed