Hand over computer screen

Prof. Dr Beat Lutz

Scientific Managing Director LIR, Professor and Director of Institute of Physiological Chemistry University Medical Center of the Johannes Gutenberg-University Mainz


Leibniz-Institut für Resilienzforschung gGmbH

Wallstraße 7
55122 Mainz

+49 (0)6131 89448-37

Office (8:30 am to 3:00 pm)
E-mail: verena.huber@lir-mainz.de
Phone: +49 (0)6131-89448-77


Behavioral Genetics in mouse. Mechanisms underlying learning and memory, and stress coping. Epigenetic mechanisms underlying behavior. Lipid signaling systems (mainly on endocannabinoids and cannabinoid receptors). Roles of the endocannabinoid system in anxiety, fear memory, stress coping, synaptic plasticity, adult neurogenesis, neural development, and energy metabolism.

General Information
Year of Birth


Current Position

Scientific Managing Director and Research Group Leader Leibniz Institute for Resilience Research (LIR), Mainz, Germany

Professor and Director Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg-University Mainz

University training and degrees

Habilitation in Zoology at the LMU Munich, Germany (Prof. G. Neuweiler)


Diploma for Gymnasium teacher in chemistry, Swiss Federal Institute of Technology (ETH)


Dr. sc. nat: Swiss Federal Institute of Technology (ETH) Zurich at Institute for Cell Biology, Switzerland (supervisor: Prof. Dr. Markus Lezzi)


Doctorate work at the Institute for Cell Biology, ETH Zurich, Switzerland (Prof. M. Lezzi, Prof. H. Eppenberger)


Diploma in Natural Sciences at ETH Zurich, Switzerland


Studies in Biochemistry at ETH Zurich, Switzerland

Advanced academic qualifications

Dr. sc. nat.: Swiss Federal Institute of Technology (ETH) Zurich at Institute for Cell Biology, Switzerland (supervisor: Prof. Dr. Markus Lezzi)

Postgraduate professional career
Since 1/2020

Scientific Managing Director and Research Group Leader, Leibniz Institute for Resilience Research (LIR), Mainz, Germany

Since 1/2018

Scientific Managing Director and Research Group Leader, Institute for Resilience Research, Mainz, Germany

Since 1/2009

Director of the Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany

Since 10/2004

W3 Professor for Physiological Chemistry, Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University, Mainz, Germany

04/1997 – 09/2004

Independent Group Leader of the Max Planck Society at the Max Planck Institute of Psychiatry, Munich, Germany

04/1995 – 03/1997

Scientist at the DKFZ, Heidelberg, Germany (Prof. G. Schütz)

04/1989 – 03/1995

Postdoctoral positions at ETH (Zurich, Switzerland; Prof. M. Lezzi), Harvard Medical School, Boston, MA USA (Prof. G. Eichele), and Baylor College of Medicine, Houston, TX, USA (Prof. G. Eichele)


Other professional activities or honors
Since 2016

Spokesperson of the CRC1193 „Neurobiology of Resilience“

Since 2016

Tenure Commission at UM Mainz, Germany

Since 2015

Co-organizer of the International Symposium on Resilience Research

Since 2014

Member of Fachbereichsrat at UM Mainz, Germany


Chair of the Gordon Research Conference “Cannabinoid Functions in the CNS”

2008 – 2014

Chairperson of DFG Research Unit FOR926 (with A. Zimmer, Bonn, Germany)

2003 – 2004

Stipend from the Hertie-Foundation (Excellence Program in Neurosciences)


Organon Prize for Psychiatry

1990 – 1994

Fellowships from the Swiss National Foundation


Selected Publications

Aparisi Rey A, Karaulanov E, Sharopov S, Arab K, Schäfer A, Gierl M, Guggenhuber S, Brandes C, Pennella L, Gruhn WH, Jelinek R, Maul C, Conrad A, Kilb W, Luhmann HJ, Niehrs C*, Lutz B* (2019) Gadd45α modulates aversive learning through post-transcriptional regulation of memory-related mRNAs. EMBO Rep 20(6):e46022. doi: 10.15252/embr.201846022. *equal contribution

>> Link to Pubmed

Zimmermann T, Maroso M, Beer A, Baddenhausen S, Ludewig S, Fan W, Vennin C, Loch S, Berninger B, Hofmann C, Korte M, Soltesz I, Lutz B*, Leschik J* (2018) Neural stem cell lineage-specific cannabinoid type-1 receptor regulates neurogenesis and plasticity in the adult mouse hippocampus. Cerebral Cortex 28(12):4454−4471. *equal contribution

>> Link to Pubmed

Ruiz de Azua I, Mancini G, Srivastava RK, Rey AA, Cardinal P, Tedesco L, Zingaretti CM, Sassmann A, Quarta C, Schwitter C, Conrad A, Wettschureck N, Vemuri VK, Makriyannis A, Hartwig J, Mendez-Lago M, Bindila L, Monory K, Giordano A, Cinti S, Marsicano G, Offermanns S, Nisoli E, Pagotto U, Cota D, Lutz B (2017) Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages. J Clin Invest 127(11):4148−4162.

>> Link to Pubmed

Lange MD, Daldrup T, Remmers F, Szkudlarek HJ, Lesting J, Guggenhuber S, Ruehle S, Jungling K, Sei-denbecher T, Lutz B, Pape HC (2017) Cannabinoid CB1 receptors in distinct circuits of the extended amygdala determine fear responsiveness to unpredictable threat. Mol Psychiatry 22(10):1422−1430.

>> Link to Pubmed

Busquets-Garcia A, Gomis-Gonzalez M, Srivastava RK, Cutando L, Ortega-Alvaro A, Ruehle S, Remmers F, Bindila L, Bellocchio L, Marsicano G, Lutz B*, Maldonado R*, Ozaita A* (2016) Peripheral and central CB1 cannabinoid receptors control stress-induced impairment of memory consolidation. Proc Natl Acad Sci USA 113(35):9904−9909. *equal contribution

>> Link to Pubmed

Lomazzo E, Bindila L, Remmers F, Lerner R, Schwitter C, Hoheisel U, Lutz B (2015) Therapeutic potential of inhibitors of endocannabinoid degradation for the treatment of stress-related hyperalgesia in an animal model of chronic pain. Neuropsychopharmacol 40:488-501.

>> Link to Pubmed

Pascual Cuadrado D, Todorov H, Lerner R, Islami L, Bindila L, Gerber S, Lutz B (2022) Long-term molecular differences between resilient and susceptible mice after a single traumatic exposure. Br J Pharmacol 179(17):4161-4180. doi: 10.1111/bph.15697

>> Link to Pubmed

Ruehle S, Remmers F, Romo-Parra H, Massa F, Wickert M, Wörtge S, Häring M, Kaiser N, Marsicano G, Pape HC, Lutz B (2013) Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons: distinctive sufficiency for hippocampus-dependent and amygdala-dependent synaptic and behavioral functions. J Neurosci 33:10264-77.

>> Link to Pubmed

Rey AA, Purrio M, Viveros MP, Lutz B (2012) Biphasic effects of cannabinoids in anxiety responses: CB1 and GABAB receptors in the balance of GABAergic and glutamatergic neurotransmission. Neuropsychopharmacol 37:2624–34.

>> Link to Pubmed

Monory K, Massa F, Egertova M, Eder M, Blaudzun H, Westenbroek R, Kelsch W, Jacob W, Marsch R, Ekker M, Long J, Rubenstein JL, Goebbels S, Nave KA, During M, Klugmann M, Wolfel B, Dodt HU, Zieglgänsberger W, Wotjak CT, Mackie K, Elphick MR, Marsicano G, Lutz B (2006) The endocanna-binoid system controls key epileptogenic circuits in the hippocampus. Neuron 51:455−466.

>> Link to Pubmed

Marsicano G, Wotjak CW, Azad SC, Bisogno T, Rammes G, Song T, Hofmann C, Zieglgänsberger W, Di Marzo V, Lutz B (2002) The endogenous cannabinoid system controls extinction of aversive memories. Nature 418:530-5.

>> Link to Pubmed
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