Prof. Dr Klaus Lieb

Scientific Managing Director LIR, Professor for Psychiatry and Psychotherapy University Medical Center of the Johannes Gutenberg-University Mainz


Leibniz-Institut für Resilienzforschung gGmbH
Wallstraße 7
55122 Mainz

+49 (0)6131 89448-24

Office (8:30 am to 3:30 pm)
E-mail: verena.huber@lir-mainz.de
Phone: +49 (0)6131-89448-77

General Information
Year of birth


Current position

Scientific Managing Director and Research Group Leader, Leibniz Institute for Resilience Research (LIR), Mainz, Germany

Professor for Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany

University training and degrees

“Habilitation” in Psychiatry, University of Freiburg, Germany


Board exam and specialization in Psychiatry and Psychotherapy

1994 – 1999

Residency at the Department of Psychiatry and Psychotherapy and Neurology, University of Freiburg, Germany

1992 – 1994

Postdoctoral fellow, Department of Anatomy and Cell Biology and Internal Medicine, University of Ulm, Germany

1985 – 1992

Medical School and Philosophy, University of Ulm and Tübingen, Germany and Los Angeles, USA

Advanced academic qualifications

Dr. med. degree, University of Ulm, Germany (summa cum laude), Department of Internal Medicine, Prof. Dr. H. L. Fehm)

Postgraduate professional career
Since 01/2020

Scientific Managing Director, Leibniz Institute for Resilience Research (LIR), Mainz, Germany

Since 01/2018

Scientific Managing Director, German Resilience Center (DRZ), Mainz, Germany

Since 04/2007

Professor for Psychiatry and Psychotherapy (W3) and Director, Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg University, Mainz, Germany

06/2001 – 03/2007

Chief Physician and Vice Chairman at the Department of Psychiatry and Psychotherapy of the University Medical Center Freiburg, Germany

02/1999 – 05/2001

Consultant psychiatrist and group leader, University Medical Center Freiburg, Germany

09/1994 – 08/1995

Postdoctoral fellow of the German Research Foundation (DFG) in the Neurobiology Laboratory of the University Hospital for Psychiatry, Freiburg, Germany

Other professional activities or honors
Up to date

Since 1994 continuing funding by DFG, BMBF, Hertie Foundation, VolkswagenFoundation, EU, and other organizations. Total amount of own third party-funded projects with external evaluation: > 5 Mio. €


Hochschullehrer des Jahres (Deutscher Hochschulverband)


Hamburger Preis Persönlichkeitsstörungen

Since 2009

Official member of the Drug Commission of the German Medical Association

Since 2009

Editor Cochrane Library of systematic reviews (section personality disorders)


Golden Helix Award


Hormosan-Forschungspreis Psychiatrie


Stipend of DFG, University of Freiburg, Germany

Selected Publications

Reinhardt S, Stoye N, Luderer M, Kiefer F, Schmitt U, Lieb K, Endres K (2018) Identification of disulfiram as a secretase-modulating compound with beneficial effects on Alzheimer's disease hallmarks. Sci Rep 8(1):1329. doi: 10.1038/s41598-018-19577-7

>> Link to Pubmed

Lieb K, Dreimüller N, Wagner S, Schlicht K, Falter T, Neyazi A, Müller-Engling L, Bleich S, Tadić A, Frieling H. (2018) BDNF plasma levels and BDNF exon IV promoter methylation as predictors for antidepressant treatment response. Front Psychiatry 9:511. doi: 10.3389/fpsyt.2018.00511

>> Link to Pubmed

Chmitorz A, Kunzler A, Helmreich I, Tüscher O, Kalisch R, Kubiak T, Wessa M, Lieb K (2018) Intervention studies to foster resilience – A systematic review and proposal for a resilience framework in future intervention studies. Clin Psychol Rev 59:78–100.

>> Link to Pubmed

Sebastian A, Rössler K, Wibral M, Mobascher A, Lieb K, Jung P, Tüscher O (2017) Neural architecture of selective stopping strategies: Distinct brain activity patterns are associated with attentional capture but not with outright stopping. J Neurosci 37(40):9785–9794.

>> Link to Pubmed

Tadić A, Wachtlin D, Berger M, Braus DF, van Calker D, Dahmen N, Dreimüller N, Engel A, Gorbulev S, Helmreich I, Kaiser A, Kronfeld K, Schlicht KF, Tüscher O, Wagner S, Hiemke C, Lieb K (2016) Randomized controlled study of early medication change for non-improvers to antidepressant therapy in major depression – The EMC trial. Eur Neuropsychopharmacol 26(4):705–716.

>> Link to Pubmed

Tadić A, Müller-Engling L, Schlicht KF, Kotsiari A, Dreimüller N, Kleimann A, Bleich S, Lieb K, Frieling H (2014) Methylation of the promotor of brain-derived neurotrophic factor exon IV and antidepressant re-sponse in major depression. Mol Psychiatry 19(3):281–283.

Stoffers JM, Völlm B, Rücker G, Timmer A, Huband N, Lieb K (2012) Psychological therapies for people with borderline personality disorder. Cochrane Database Syst Rev (8):CD005652. doi: 10.1002/14651858.CD005652.pub2

>> Link to Pubmed

Rüsch N, Lieb K, Göttler I, Hermann C, Schramm E, Richter H, Jacob GA, Corrigan P, Bohus M (2007) Shame and implicit self-concept in women with borderline personality disorder. Am J Psychiatry 164(3):500–508.

>> Link to Pubmed

Lieb K, Zanarini MC, Schmahl C, Linehan MM, Bohus M (2004) Borderline personality disorder. Lancet 364:453–461.

>> Link to Pubmed

Lieb K, Brucker S, Bach M, Els T, Lücking CH, Greenlee MW (1999) Impairment in preattentive visual pro-cessing in patients with Parkinson's disease. Brain 122:303–313.

>> Link to Pubmed
Leibniz Institute for Resilience Research (LIR)
Wallstraße 7
55122 Mainz
Phone: +49 (0)6131 89448-24
Further Information