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Prof. Dr Marianne Müller

Research Group Leader, Professor for Psychiatry and Psychotherapy University Medical Center of the Johannes Gutenberg-University Mainz


Leibniz-Institut für Resilienzforschung gGmbH
Hanns-Dieter-Hüsch-Weg 19
55128 Mainz

+49 (0)6131 39-30297
General Information
Year of Birth


Current Position

Research Group Leader, Leibniz Institute for Resilience Research (LIR), Mainz, Germany

Professor, Department of Psychiatry and Psychotherapy and Focus Program Translational Neurosciences (FTN), University Medical Center of the Johannes Gutenberg University, Mainz, Germany

University training and degrees

M.D. degree award (magna cum laude); Institute of Neuropathology, University of Bonn, Germany (supervisor: Prof. Dr. O.D. Wiestler)

10/1989 – 11/1995

Medical School, University of Bonn, Germany; speciality subject: Psychiatry (state examination 11/1995)


Advanced academic qualifications

Privatdozentin (Habilitation); Venia Legendi in Psychiatry and Psychotherapy, Ludwig Maximilian University Munich, Germany


Postgraduate professional career
Since 01/2020

Research Group Leader and Head of Mouse Behaviour Unit (MBU) at the Leibniz Institute for Resilience Research (LIR), Mainz, Germany

Since 01/2018

Research Group Leader and Head of Mouse Behaviour Unit (MBU) at the German Resilience Center (DRZ) Mainz, Germany

Since 03/2014

Professor of Translational Psychiatry (permanent position), Head of Section Translational Psychiatry. University Medical Center of the Johannes Gutenberg University and Focus Program Translational Neuroscience, Mainz, Germany

01/2004 – 12/2013

Head, Independent Research Group Molecular Stress Physiology (Career breaks due to parental leave 02/2007 − 08/2007 and 08/2010 − 02/2011)

Since 2004

Minerva Program (Professorship Award/W2 for outstanding female scientists) from the Max Planck Society, Germany

01/2004 – 11/2007

Assistant Medical Director, Open Psychiatric Ward (Oberärztin)


Board certification in Psychiatry (Fachärztin für Psychiatrie und Psychotherapie)

07/1996 – 12/2003

Residency in Psychiatry and Neurology; clinical training

04/1997 – 10/1997

Visiting scientist at the Netherlands Institute for Brain Research, Amsterdam, the Netherlands (supervisor: Prof. Dr. D.F. Swaab)

07/1996 – 12/2003

Postdoctoral Researcher, Molecular Neurogenetics Group (supervisor: Prof. Dr. W. Wurst)

01/1996 – 06/1996

Postdoctoral Fellow, Department of Neuropathology, University of Bonn Medical Center, Germany (supervisor: Prof. Dr. O. D. Wiestler)

Selected Publications

van der Kooij MA, Jene T, Treccani G, Miederer I, Hasch A, Voelxen N, Walenta S, Müller MB (2018) Chronic social stress-induced hyperglycemia in mice couples individual stress susceptibility to impaired spatial memory. Proc Natl Acad Sci USA 115(43):E10187−E10196.

>> Link to Pubmed

Carrillo-Roa T, Labermaier C, Weber P, Herzog DP, Lareau C, Santarelli S, Wagner KV, Rex-Haffner M, Harbich D, Scharf SH, Nemeroff CB, Dunlop BW, Craighead WE, Mayberg HS, Schmidt MV, Uhr M, Hols-boer F, Sillaber I, Binder EB, Müller MB (2017) Common genes associated with antidepressant response in mouse and man identify key role of glucocorticoid receptor sensitivity. PLoS Biol 15(12):e2002690. doi: 10.1371/journal.pbio.2002690.

>> Link to Pubmed

van der Kooij MA, Masana M, Rust MB, Müller MB (2016) The stressed cytoskeleton: how actin dynamics can shape stress-related consequences on synaptic plasticity and complex behavior. Neurosci Biobehav Rev 62:69–75.

>> Link to Pubmed

Kalisch R, Müller MB, Tüscher O (2015) A conceptual framework for the neurobiological study of resilience. Behav Brain Sci 38:e92. doi: 10.1017/S0140525X1400082.

>> Link to Pubmed

Kalisch R, Müller MB, Tüscher O (2015) Advancing empirical resilience research. Behav Brain Sci 38: e128. doi: 10.1017/S0140525X15000023.

>> Link to Pubmed

Wang XD, Su Y, Wagner KV, Avrabos C, Scharf SH, Hartmann J, Wolf M, Liebl C, Kühne C, Wurst W, Holsboer F, Eder M, Deussing JM, Müller MB, Schmidt MV (2013) Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss. Nat Neurosci 16(6):706−713.

>> Link to Pubmed

Schmidt MV, Schülke J-P, Liebl C, Stiess M, Avrabos C, Bock J, Wochnik GM, Davies HA, Zimmermann N, Scharf SH, Trümbach D, Wurst W, Zieglgänsberger W, Turck C, Holsboer F, Stewart MG, Bradke F, Eder M, Müller MB*, Rein T* (2011) Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition. Proc Natl Acad Sci USA 108(41):17213−17218. *equal contribution. This paper was highlighted in Research Highlights in Nature (Stress alters brain connections (2011) Nature 478:159)

>> Link to Pubmed

Lucae S, Sämann PG, Schmidt MV, Demirkan A, Hek K, Roeske D, Alexander M, Salyakina D, Ripke S, Höhn D, Specht M, Menke A, Hennings J, Heck A, Wolf C, Ising M, Schreiber S, Czisch M, Müller MB, Uhr M, Bettecken T, Beckers A, Schramm J, Rietschel M, Maier W, Bradley B, Ressler KJ, Nöthen MM, Cichon S, Craig IW, Breen G, Lewis CM, Hofman A, Tiemeier H, van Duijn CM, Holsboer F, Müller-Myhsok B, Binder EB (2011) The neuronal transporter gene SLC6A15 confers risk to major depression. Neuron 70(2):252–265.

>> Link to Pubmed

Schmidt MV, Trümbach D, Weber P, Wagner K, Scharf SH, Liebl C, Datson N, Namendorf C, Gerlach T, Kühne C, Uhr M, Deussing JM, Wurst W, Binder EB, Holsboer F, Müller MB (2010) Individual stress vulnerability is predicted by short-term memory and AMPA receptor subunit ratio in the hippocampus. J Neurosci 30(50):16949–16958.

>> Link to Pubmed

Müller MB, Zimmermann S, Sillaber I, Hagemeyer TP, Timpl P, Kormann MSD, Droste S, Deussing JM, Kühn R, Reul JMHM, Holsboer F, Wurst W (2003) Limbic corticotropin-releasing hormone receptor 1 medi-ates anxiety-related behavior and hormonal adaptation to stress. Nat Neurosci 6(10):1100−1107.

>> Link to Pubmed
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